• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Royal Society Proceedings B: Biological Sciences >On the adaptive significance of stress-induced immunosuppression.
【24h】

On the adaptive significance of stress-induced immunosuppression.

机译：关于应激诱导的免疫抑制的适应性意义。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We approach the field of stress immunology from an ecological point of view and ask: why should a heavy physical workload, for example as a result of a high reproductive effort, compromise immune function? We argue that immunosuppression by neuroendocrine mechanisms, such as stress hormones, during heavy physical workload is adaptive, and consider two different ultimate explanations of such immunosuppression. First, several authors have suggested that the immune system is suppressed to reallocate resources to other metabolic demands. In our view, this hypothesis assumes that considerable amounts of energy or nutrients can be saved by suppressing the immune system; however, this assumption requires further investigation. Second, we suggest an alternative explanation based on the idea that the immune system is tightly regulated by neuroendocrine mechanisms to avoid hyperactivation and ensuing autoimmune responses. We hypothesize that the risk of autoimmune responses increases during heavy physical workload and that the immune system is suppressed to counteract this.
机译：我们从生态学的角度研究应激免疫学领域，并提出一个问题：为什么繁重的体力劳动（例如由于繁重的生殖努力）会损害免疫功能？我们认为，在繁重的体力劳动过程中，通过神经内分泌机制（例如应激激素）进行的免疫抑制是适应性的，并考虑了这种免疫抑制的两种不同的最终解释。首先，一些作者建议抑制免疫系统以将资源重新分配给其他代谢需求。我们认为，该假设假设通过抑制免疫系统可以节省大量能量或营养。但是，此假设需要进一步调查。其次，我们基于免疫内分泌机制严密调节免疫系统以避免过度激活和随之而来的自身免疫反应的想法，提出了另一种解释。我们假设在繁重的体力劳动过程中自身免疫反应的风险增加，并且免疫系统被抑制以抵消这一风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号