首页> 外文期刊>The Royal Society Proceedings B: Biological Sciences >Experience-dependent modulation of tonotopic neural responses in human auditory cortex.
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Experience-dependent modulation of tonotopic neural responses in human auditory cortex.

机译:经验依赖的人类听觉皮层中的tonotopic神经反应的调制。

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Experience-dependent plasticity of receptive fields in the auditory cortex has been demonstrated by electrophysiological experiments in animals. In the present study we used PET neuroimaging to measure regional brain activity in volunteer human subjects during discriminatory classical conditioning of high (8000 Hz) or low (200 Hz) frequency tones by an aversive 100 dB white noise burst. Conditioning-related, frequency-specific modulation of tonotopic neural responses in the auditory cortex was observed. The modulated regions of the auditory cortex positively covaried with activity in the amygdala, basal forebrain and orbitofrontal cortex, and showed context-specific functional interactions with the medial geniculate nucleus. These results accord with animal single-unit data and support neurobiological models of auditory conditioning and value-dependent neural selection.
机译:通过动物的电生理实验证明了听觉皮层感受野的经验依赖性可塑性。在本研究中,我们使用PET神经影像技术通过歧视性的100 dB令人讨厌的白噪声猝发,在歧视性的高(8000 Hz)或低(200 Hz)频率音调经典条件下,测量了志愿者人类受试者的局部大脑活动。在听觉皮层中观察到了与条件相关的,频率特定的调变性对听神经皮层神经反应的调节。听觉皮层的调制区域与杏仁核,基底前脑和眶额叶皮层中的活动正相关,并显示与内侧膝状核的上下文特定功能相互作用。这些结果符合动物单单位数据,并支持听觉条件和价值依赖型神经选择的神经生物学模型。

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