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首页> 外文期刊>The Royal Society Proceedings B: Biological Sciences >Amiloride causes changes in the mechanical properties of hair cell bundles in the fish lateral line similar to those induced by dihydrostreptomycin
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Amiloride causes changes in the mechanical properties of hair cell bundles in the fish lateral line similar to those induced by dihydrostreptomycin

机译：阿米洛利引起鱼侧线毛细胞束机械特性的改变，类似于二氢链霉素诱导的改变

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Amiloride is a known blocker of the mechano-electrical transduction current in sensory hair cells. Measurements of cupular motion in the lateral line organ of fish now show that amiloride concurrently changes the micromechanical properties of the hair cell bundles. The effects of amiloride on the mechanics and receptor potentials of the hair cells resemble those previously observed for the aminoglycoside drug dihydrostreptomycin (DHSM) and are similarly antagonized by Ca2+. We hypothesize that amiloride and DHSM act on hair cells in two correlated ways, which manifest themselves in both the electrical and mechanical properties of the transduction process. One action is the reduction of the transduction current with a concurrent increase in hair bundle stiffness. The other action is a shift of the hair cell's operating point on a current-displacement curve, with a concomitant shift along the associated hair bundle stiffness-displacement curve. The latter action has the opposite effect to that of the first and thus may lead, at relatively low blocker concentrations, to both an increase of transduction current and a decrease in hair bundle stiffness. [References: 35]
机译：阿米洛利是已知的感官毛细胞中机电转导电流的阻滞剂。对鱼的侧线器官中的杯形运动的测量现在表明，阿米洛利同时改变了毛细胞束的微机械性能。阿米洛利对毛细胞力学和受体电位的影响类似于以前对氨基糖苷类药物二氢链霉素（DHSM）观察到的效果，并且类似地被Ca2 +拮抗。我们假设阿米洛利和DHSM以两种相关的方式作用于毛细胞，这在转导过程的电学和机械特性中均表现出来。一种作用是减少转导电流，同时增加发束的刚度。另一个作用是在当前位移曲线上移动毛细胞的工作点，并伴随着相关的发束刚度-位移曲线移动。后一种作用与第一种作用相反，因此在相对较低的阻滞剂浓度下可能导致转导电流增加和发束刚度降低。 [参考：35]

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