• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Royal Society Proceedings B: Biological Sciences >Gap junctions with amacrine cells provide a feedback pathway for ganglion cells within the retina.
【24h】

Gap junctions with amacrine cells provide a feedback pathway for ganglion cells within the retina.

机译：与无长突细胞的间隙连接为视网膜内的神经节细胞提供了反馈途径。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In primates, one type of retinal ganglion cell, the parasol cell, makes gap junctions with amacrine cells, the inhibitory, local circuit neurons. To study the effects of these gap junctions, we developed a linear, mathematical model of the retinal circuitry providing input to parasol cells. Electrophysiological studies have indicated that gap junctions do not enlarge the receptive field centres of parasol cells, but our results suggest that they make other contributions to their light responses. According to our model, the coupled amacrine cells enhance the responses of parasol cells to luminance contrast by disinhibition. We also show how a mixed chemical and electrical synapse between two sets of amacrine cells presynaptic to the parasol cells might make the responses of parasol cells more transient and, therefore, more sensitive to motion. Finally, we show how coupling via amacrine cells can synchronize the firing of parasol cells. An action potential in a model parasol cell can excite neighbouring parasol cells, but only when the coupled amacrine cells also fire action potentials. Passive conduction was ineffective due to low-pass temporal filtering. Inhibition from the axons of the coupled amacrine cells also produced oscillations that might synchronize the firing of more distant ganglion cells.
机译：在灵长类动物中，一种类型的视网膜神经节细胞，即阳伞细胞，与无长突神经元细胞（即抑制性局部回路神经元）形成间隙连接。为了研究这些间隙连接的作用，我们开发了视网膜电路的线性数学模型，为阳伞细胞提供输入。电生理研究表明，缝隙连接不会扩大阳伞细胞的感受野中心，但我们的结果表明它们对光反应做出了其他贡献。根据我们的模型，偶合的无长突细胞通过去抑制作用增强了阳伞细胞对亮度对比度的响应。我们还显示了在前突触到阳伞细胞的两组无长突细胞之间的化学和电突触混合如何使阳伞细胞的反应更短暂，因此对运动更敏感。最后，我们展示了通过无长突细胞的偶联如何同步遮阳伞细胞的发射。模型阳伞细胞中的动作电位可以激发邻近的阳伞细胞，但仅当偶合的无长突细胞也激发动作电位时才如此。由于低通时间滤波，被动传导无效。来自偶合的无长突细胞轴突的抑制作用还产生振荡，该振荡可能与更远的神经节细胞的发射同步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号