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首页> 外文期刊>The Royal Society Proceedings B: Biological Sciences >Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class.
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Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class.

机译：5-羟色胺1受体类介导5-羟色胺诱导的大鼠离体脊髓运动节律的抑制。

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摘要

The neurotransmitter serotonin (5-HT) induces rhythmic motor patterns (fictive locomotion) of the neonatal rat spinal cord in vitro; this is a useful experimental model to study the generation of a motor programme at exclusively spinal level. Nevertheless, 5-HT slows down the fictive locomotion typically elicited by activation of NMDA glutamate receptors, suggesting a complex action of this monoamine. By means of electrophysiological recordings from multiple ventral roots we demonstrated that the decrease caused by 5-HT in NMDA-induced periodicity was dose-dependent, enhanced after pharmacological blocking of 5-HT2 excitatory receptors, and imitated by pharmacological agonists of the 5-HT1 receptor family. Selective blockers of the 5-HT1A or 5-HT1B/D receptor classes, either alone or in combination, largely (but not completely) attenuated this inhibitory action of 5-HT. It is concluded that the principal inhibitory action of 5-HT on the spinal locomotor network was mediated by certain subtypes of the 5-HT1 receptor class, which tends to oppose the 5-HT2 receptor-mediated excitation of the same network.
机译：神经递质5-羟色胺（5-HT）在体外诱导新生大鼠脊髓的节律性运动模式（虚构的运动）。这是一个有用的实验模型，可用于专门研究脊柱水平的运动程序的生成。然而，5-HT减慢了通常由NMDA谷氨酸受体激活引起的假想运动，表明该单胺的复杂作用。通过多个腹侧根部的电生理记录，我们证明了NMDA诱导的周期中5-HT引起的降低是剂量依赖性的，在药理上阻断5-HT2兴奋性受体后增强，并被5-HT1的药理激动剂所模仿受体家族。单独或组合使用5-HT1A或5-HT1B / D受体选择性阻滞剂可大大（但不完全）减弱5-HT的这种抑制作用。结论是5-HT对脊髓运动网络的主要抑制作用是由5-HT1受体类别的某些亚型介导的，它倾向于与5-HT2受体介导的同一网络的兴奋作用相反。

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