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首页> 外文期刊>The Royal Society Proceedings B: Biological Sciences >The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks
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The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks

机译：痒病的特征：受痒病影响和无痒病的英国羊群的PrP基因型谱差异

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The amino-acid sequence of the PrP protein plays an important role in determining whether sheep are susceptible to scrapic. Although the genetics of scrapie susceptibility are now well understood, there have been few studies of the PrP gene at the population level, especially in commercially farmed sheep. Here we describe the PrP genetic profiles of the breeding stock of four UK sheep flocks, comprising nearly 650 animals in total. Two flocks had been scrapie affected for about eight years and two were scrapie free. Scrapie-resistant PrP genotypes predominated in all flocks but highly susceptible genotypes were present in each case. The distribution of PrP genotypes was similar in the scrapie-affected and scrapie-free flocks. The former, however, showed a slight but significant skew towards more susceptible genotypes despite their previous losses of susceptible sheep. Surprisingly, this skew was apparent in younger, but not older, sheep. We suggest that these patterns may occur if sheep Becks destined to become scrapie affected are predisposed by a genetic profile skewed towards susceptibility The age structure of the scrapie-affected flocks suggests that the number of losses attributable directly or indirectly to scrapie considerably exceeds that recognized by the farmers, and also that significant losses may occur even in sheep of a moderately susceptible genotype. Similar patter ns were not detected in the scrapie-free flocks, indicating that these losses are associated with scrapie infection as well as genotype. [References: 17]
机译：PrP蛋白的氨基酸序列在确定绵羊是否易受刮伤中起着重要作用。尽管现在对瘙痒病易感性的遗传学已有很好的了解，但是在种群水平上，特别是在商业化养殖的绵羊中，对PrP基因的研究很少。在这里，我们描述了四只英国羊群的繁殖种群的PrP遗传概况，总共包括近650只动物。两只羊群受到瘙痒病的影响约八年，其中两群没有瘙痒病。耐刮flo的PrP基因型在所有鸡群中均占主导地位，但在每种情况下均存在高度易感的基因型。在受瘙痒病影响和无瘙痒病的鸡群中，PrP基因型的分布相似。尽管前者失去了易感绵羊，但前者向易感基因型显示出轻微但明显的偏斜。出人意料的是，这种偏斜在较年轻但不较老的绵羊中很明显。我们建议，如果注定易受羊痒病影响的绵羊Becks易受易感性遗传特性的影响，可能会出现这些模式。受羊痒病影响的羊群的年龄结构表明，直接或间接归因于羊痒病的损失数量大大超过农民，而且即使是中度易感基因型的绵羊也可能遭受重大损失。在无瘙痒病的鸡群中未检测到相似的模式，表明这些损失与瘙痒病感染以及基因型相关。 [参考：17]

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