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首页> 外文期刊>The Southeast Asian journal of tropical medicine and public health >Validation of osmotic fragility test and dichlorophenol indophenol precipitation test for screening of thalassemia and hb e.
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Validation of osmotic fragility test and dichlorophenol indophenol precipitation test for screening of thalassemia and hb e.

机译：渗透性脆性试验和二氯苯酚吲哚酚沉淀试验用于地中海贫血和血红蛋白筛查的验证。

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摘要

The strategy for screening of thalassemia and Hb E by a combination of osmotic fragility (OF) test and dichlorophenol indophenol precipitation (DCIP) test was validated with 436 unrelated Thai subjects. Hemoglobin (Hb) typing, Hb A2 quantitation, PCR and DNA sequence analysis were used as confirmatory methods for diagnosis of thalassemia and hemoglobinopathy. The sensitivity and specificity of this strategy was 100% and 79.7%, respectively. The results assessed by two medical scientists were exactly the same with 93.3% accuracy in comparison with the confirmatory methods. A combination of OF and DCIP has been shown to be a reliable, rapid, simple and sensitive strategy for screening thalassemia and Hb E in the Thai population.
机译：通过渗透性脆弱性（OF）测试和二氯酚吲哚酚沉淀（DCIP）测试相结合的方法筛选地中海贫血和Hb E的策略已在436名泰国无关受试者中得到验证。血红蛋白（Hb）分型，Hb A2定量，PCR和DNA序列分析被用作诊断地中海贫血和血红蛋白病的确认方法。该策略的敏感性和特异性分别为100％和79.7％。与确认方法相比，两位医学科学家评估的结果完全相同，准确度为93.3％。 OF和DCIP的结合已被证明是筛查泰国人群地中海贫血和Hb E的可靠，快速，简单和敏感的策略。

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