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首页> 外文期刊>The Southeast Asian journal of tropical medicine and public health >DIPHTHERIA OUTBREAK IN THAILAND, 2012; SEROPREVALENCE OF DIPHTHERIA ANTIBODIES AMONG THAI ADULTS AND ITS-IMPLICATIONS FOR IMMUNIZATION PROGRAMS
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DIPHTHERIA OUTBREAK IN THAILAND, 2012; SEROPREVALENCE OF DIPHTHERIA ANTIBODIES AMONG THAI ADULTS AND ITS-IMPLICATIONS FOR IMMUNIZATION PROGRAMS

机译：2012年泰国突尼斯疫情;泰国成年人中双歧杆菌的血清学鉴定及其对免疫计划的启示

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摘要

An age distribution shift in diphtheria cases during a 2012 outbreak in northeastern of Thailand suggests adults are increasingly at risk for infection in Thailand. Data regarding immunity against diphtheria among the adult Thai population is limited. We review a 2012 diphtheria outbreak in Thailand and conducted a nationwide seroepidemiological survey to determine the prevalence of diphtheria antibodies among Thai adults in order to inform immunization programs. A total of 41 confirmed cases, 6 probable cases and 101 carriers of diphtheria were reported from northeastern and upper southern Thailand. The diphtheria outbreak in northeastern Thailand occurred among adults aged >15 years; sporadic cases occurred among children from upper southern Thailand. We conducted a seroepidemiological survey of 890 Thai adults from 4 age groups (20-29,30-39, 40-49 and 50-59 years) in 7 different geographical areas of Thailand (Chiang Mai, Ratchaburi, Chon Buri, Nakhon Si Thammarat, Phitsanulok, Khon Kaen and Songkhla). Diptheria toxin antibody levels were measured with a commercially available ELISA test. The seroprotection rate ranged from 83% to 99%, with the highest in eastern Thailand (Chon Buri, 99%) and the lowest in northern Thailand (Chiang Mai, 83%). Diphtheria antibodies declined with increasing age. We recommend one dose of diphtheria-tetanus toxoid (dT) vaccine once after 20 years of age in order to boost the antibody and revaccinations every 10 years to prevent future outbreaks.
机译：在泰国东北部2012年爆发的白喉病例中，年龄分布发生了变化，这表明泰国成年人的感染风险越来越高。关于泰国成年人口中对白喉免疫力的数据有限。我们回顾了2012年泰国发生的白喉疫情，并进行了全国血清流行病学调查，以确定泰国成年人中白喉抗体的流行程度，以便为免疫计划提供信息。泰国东北部和南部上部地区共报告确诊病例41例，可能病例6例，携带白喉101例。在泰国东北部，白喉暴发发生在15岁以上的成年人中。零星的病例发生在泰国南部的儿童中。我们对泰国7个不同地理区域（清迈，叻atch府，春武里府，那空是叻府）的4个年龄段（20-29、30-39、40-49和50-59岁）的890名泰国成年人进行了流行病学调查，彭世洛，孔敬和宋卡）。用可商购的ELISA测试测量白喉毒素抗体水平。血清保护率介于83％至99％之间，在泰国东部最高（春武里府，99％），在泰国北部最低（清迈，83％）。白喉抗体随着年龄的增长而下降。我们建议20岁以后服用一剂白喉-破伤风类毒素（dT）疫苗，以加强抗体，并每10年重新接种一次，以防止将来爆发。

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