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首页> 外文期刊>The Turkish journal of pediatrics >Randomized controlled trial of two methods of nasal continuous positive airway pressure (N-CPAP) in preterm infants with respiratory distress syndrome: Underwater bubbly CPAP vs. Medijet system device
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Randomized controlled trial of two methods of nasal continuous positive airway pressure (N-CPAP) in preterm infants with respiratory distress syndrome: Underwater bubbly CPAP vs. Medijet system device

机译：呼吸窘迫综合征早产儿两种鼻持续气道正压通气（N-CPAP）方法的随机对照试验：水下气泡CPAP与Medijet系统装置

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There has been an increasing interest in the application of non-invasive respiratory support in preterm infants, and different types of nasal continuous positive airway pressure (N-CPAP) devices are being used in Neonatal Intensive Care Units (NICUs). The objective of the present study was to compare the duration of CPAP need and possible complications of two methods of (N-CPAP) delivery: Bubble CPAP (B-CPAP) and Medijet (MJ) system device in preterm infants with respiratory distress syndrome (RDS). This prospective randomized clinical trial was performed on 161 preterm infants (28-37 weeks of gestational age) with RDS and eligible for CPAP therapy. The infants were inborn and admitted in a level III NICU of Al-Zahra Teaching Hospital (Tabriz, Iran) from April 2010 to September 2011. All infants were randomized in the first hour of life to B-CPAP or MJ system. Short binasal prongs were used in both groups and CPAP was set at the level of 5-6 cm H2O. The primary outcome of this study was duration of CPAP need (hour). Other outcomes, such as complications of the two methods of N-CPAP, were evaluated using a checklist. Ninety infants were randomized to the MJ system, and 71 were randomized to B-CPAP. The mean gestational age and birth weight were similar in the two groups, as was the duration of CPAP need (44.3±20.64 vs. 49.2±21.2 hours, respectively; p=0.66). Moreover, the probability of complications, such as CPAP failure rate, pulmonary hemorrhage, pneumothorax, intraventricular hemorrhage, abdominal distention, necrotizing enterocolitis, and bronchopulmonary dysplasia, was the same between the two study groups (p0.05). There was a trend of more hyperemia of the nose in the B-CPAP group in comparison to the MJ system group (10% versus 3.3%, respectively), but the difference was not significant (p=0.08). In conclusion, the MJ system is as effective as B-CPAP in the management of infants with RDS.
机译：在早产儿中应用无创呼吸支持的兴趣越来越高，新生儿重症监护病房（NICU）中使用了不同类型的鼻持续气道正压通气（N-CPAP）设备。本研究的目的是比较呼吸窘迫综合征早产儿的CPAP需求持续时间和两种（N-CPAP）分娩方式（Bubble CPAP（B-CPAP）和Medijet（MJ）系统装置）的可能并发症（ RDS）。这项前瞻性随机临床试验是针对161名接受RDS并接受CPAP治疗的早产儿（胎龄28-37周）进行的。婴儿于2010年4月至2011年9月在Al-Zahra教学医院（伊朗塔布里兹）的III级重症监护病房（NICU）出生并入院。所有婴儿在出生后的第一小时就被随机分为B-CPAP或MJ系统。两组均使用了短鼻窦插脚，CPAP设定为5-6 cm H2O的水平。这项研究的主要结果是需要CPAP的时间（小时）。使用检查表评估其他结局，例如两种N-CPAP方法的并发症。 90名婴儿被随机分配到MJ系统，71名婴儿被随机分配到B-CPAP。两组的平均胎龄和出生体重相似，需要CPAP的时间也一样（分别为44.3±20.64和49.2±21.2小时; p = 0.66）。此外，两个研究组的并发症发生率，如CPAP失败率，肺出血，气胸，脑室内出血，腹胀，坏死性小肠结肠炎和支气管肺发育不良，均相同（p> 0.05）。与MJ系统组相比，B-CPAP组存在鼻子充血的趋势（分别为10％和3.3％），但差异不显着（p = 0.08）。总之，在RDS婴儿的管理中，MJ系统与B-CPAP一样有效。

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