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首页> 外文期刊>The Pediatric infectious disease journal >Persistence of group C anticapsular antibodies two to three years after immunization with an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine.
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Persistence of group C anticapsular antibodies two to three years after immunization with an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine.

机译：使用研究性四价脑膜炎奈瑟菌-白喉类毒素结合疫苗免疫后两到三年，C组抗荚膜抗体的持久性。

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BACKGROUND: An investigational quadrivalent (A, C, Y and W-135) meningococcal conjugate (MC-4) vaccine was reported to be more immunogenic in 2-year-olds than the currently licensed meningococcal polysaccharide vaccine, but persistence of serum antibody beyond 6 months after conjugate vaccination is unknown. OBJECTIVE: Determine persistence and the immunologic basis of protective activity of group C anticapsular antibodies in sera obtained 2-3 years after MC-4 vaccination. DESIGN: Group C antibody concentrations, bactericidal activity and passive protective activity were measured in sera from 48 children, ages 4-5 years, who had been immunized 2-3 years earlier with an MC-4 vaccine and from 47 children who had not been previously vaccinated. RESULTS: Serum antibody concentrations were higher in the vaccinated than the unvaccinated children (geometric means, 0.30 and 0.09 mug/mL, respectively, P < 0.0001). Bactericidal titers > or =1/4 (considered protective) were infrequent in both vaccinated and unvaccinated children (14.6 and 6.4%, respectively, P = 0.3). Passive protective activity against bacteremia in the infant rat model was more frequent in sera from vaccinated (37.5%) than sera from unvaccinated children (12.5%, P < 0.02). The proportion of sera with passive protective activity increased with increasing anticapsular antibody concentrations (P < 0.0001). INTERPRETATION: Serum group C antibody concentrations remained elevated for 2-3 years after MC-4 vaccination, and passive protective activity was more frequent in vaccinated than unvaccinated children. However, serum antibody concentrations in many vaccinated children were no longer sufficient to activate complement-mediated bacteriolysis in vitro or to confer passive protection against experimental group C disease.
机译：背景：据报道，研究性四价（A，C，Y和W-135）脑膜炎球菌结合物（MC-4）疫苗在2岁儿童中的免疫原性比目前许可的脑膜炎球菌多糖疫苗高，但血清抗体的持久性超过结合疫苗接种后6个月未知。目的：确定MC-4疫苗接种2-3年后血清中C组抗荚膜抗体的持久性和保护活性的免疫学基础。设计：在48名4-5岁的儿童中测量了C组抗体的浓度，杀菌活性和被动保护活性，这些儿童在2-3年前使用MC-4疫苗进行了免疫，而47名儿童未进行过MC-4疫苗的免疫。先前已接种疫苗。结果：接种疫苗的儿童血清抗体浓度高于未接种疫苗的儿童（几何平均值，分别为0.30和0.09 cup / mL，P <0.0001）。接种和未接种的儿童中杀菌滴度均不大于或等于1/4（考虑到保护性）（分别为14.6％和6.4％，P = 0.3）。婴儿大鼠模型中对菌血症的被动保护活性在接种疫苗的血清中（37.5％）比未接种疫苗的儿童血清（12.5％，P <0.02）更为频繁。具有被动保护活性的血清比例随抗荚膜抗体浓度的增加而增加（P <0.0001）。解释：MC-4疫苗接种后2-3年，血清C组抗体浓度仍保持升高，并且接种疫苗的儿童比未接种疫苗的儿童更频繁地进行被动保护。但是，在许多接种疫苗的儿童中，血清抗体浓度不再足以在体外激活补体介导的溶菌作用或对实验性C组疾病提供被动保护。

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