...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Pediatric infectious disease journal >Etiology, extended-spectrum β-lactamase rates and antimicrobial susceptibility of gram-negative bacilli causing intra-abdominal infections in patients in general pediatric and pediatric intensive care units - Global data from the study for monitoring antimicrobial resistance trends 2008 to 2010
【24h】

Etiology, extended-spectrum β-lactamase rates and antimicrobial susceptibility of gram-negative bacilli causing intra-abdominal infections in patients in general pediatric and pediatric intensive care units - Global data from the study for monitoring antimicrobial resistance trends 2008 to 2010

机译：普通儿科和儿科重症监护病房患者中引起腹腔内感染的革兰氏阴性杆菌的病因学，广谱β-内酰胺酶发生率和抗菌药敏感性-2008年至2010年监测抗菌素耐药性趋势研究的全球数据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Antimicrobial resistance has been increasing for several years and is often higher in intensive care units (ICUs) than in other facilities. The spread of extended-spectrum β-lactamases (ESBLs) in particular has profoundly impacted antimicrobial efficacy and usage. The Study for Monitoring Antimicrobial Resistance Trends has monitored the in vitro activity of ertapenem and several comparators against aerobic gram-negative bacteria from intra-abdominal infections (IAIs) for many years. This report summarizes susceptibility levels and epidemiology for key IAI pathogens cultured from general pediatric medical wards and pediatric ICUs globally. Methods: 1248 gram-negative bacteria were collected from pediatric IAIs by 113 labs in 40 countries from 2008 to 2010. Susceptibility was determined by Clinical and Laboratory Standards Institute broth microdilution. Susceptibility rates (%S) were determined for species with ≥10 isolates. Results: Sixty-two percent of isolates came from general pediatric wards and 38% from pediatric ICUs. The overall ESBL-positive rate was 11.0% for Escherichia coli and 38.9% for Klebsiella pneumoniae; the ESBL-positive rate for E. coli was twice as high in ICU as non-ICU. Most study drugs inhibited >90% of ESBL-negative isolates, but only the carbapenems inhibited >90% of ESBL-positive E. coli and only imipenem inhibited >90% of ESBL-positive K. pneumoniae. Conclusions: Amikacin, imipenem and ertapenem were the most active against gram-negative bacteria from pediatric IAIs, followed closely by the fluoroquinolones and cefepime. Other cephalosporins were often <90% active. ESBL rates were 38.9% for K. pneumoniae and 11.0% for E. coli. Therapy for pediatric IAIs should take into consideration local ESBL rates because only carbapenems inhibited most of these pathogens.
机译：背景：抗菌素耐药性已经增加了几年，并且在重症监护病房（ICU）中通常比其他机构更高。广谱β-内酰胺酶（ESBLs）的扩散尤其对抗菌功效和使用产生了深远影响。监测抗菌素耐药性趋势的研究已经监测了厄他培南和几种比较剂针对来自腹腔内感染（IAIs）的好氧革兰氏阴性细菌的体外活性。本报告总结了从全球儿科医学病房和儿科ICU培养出来的关键IAI病原体的敏感性水平和流行病学。方法：2008年至2010年，在40个国家/地区的113个实验室中，从儿科IAI中收集了1248克阴性细菌。通过临床和实验室标准协会肉汤微稀释法测定了药敏性。确定了≥10个分离物的物种的药敏率（％S）。结果：62％的分离株来自普通儿科病房，38％来自儿科ICU。大肠杆菌的总ESBL阳性率为11.0％，肺炎克雷伯菌为38.9％;在ICU中，大肠杆菌的ESBL阳性率是非ICU的两倍。大多数研究药物抑制> 90％的ESBL阴性菌株，但只有碳青霉烯类抑制> 90％的ESBL阳性大肠杆菌，只有亚胺培南抑制> 90％的ESBL阳性肺炎克雷伯菌。结论：阿米卡星，亚胺培南和厄他培南对儿童IAIs革兰氏阴性菌的活性最高，其次是氟喹诺酮类和头孢吡肟。其他头孢菌素的活性通常小于90％。肺炎克雷伯菌的ESBL率为38.9％，大肠杆菌为11.0％。小儿IAI的治疗应考虑当地的ESBL率，因为只有碳青霉烯类药物才能抑制大多数这些病原体。

著录项

相似文献

  • 外文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号