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首页> 外文期刊>The Veterinary Journal >STUDIES OF CANINE LEUCOCYTE ANTIGENS - A SIGNIFICANT ADVANCE IN CANINE IMMUNOLOGY [Review]
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STUDIES OF CANINE LEUCOCYTE ANTIGENS - A SIGNIFICANT ADVANCE IN CANINE IMMUNOLOGY [Review]

机译：犬白细胞抗原的研究-犬免疫学中的重要进展[综述]

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摘要

The Canine Leucocyte Antigen Workshop (CLAW) was set up to produce and circulate monoclonal antibodies directed against cell surface molecules defining specific leucocyte cell types in the dog. The antibodies produced by the workshop have been used in studies of the canine immune system. While many similarities between the dog and other animals have been demonstrated, workshop studies have identified some anomalies in this species: CD4 antigen for example is expressed not only helper/inducer T-lymphocytes but also at high density on canine neutrophils. Workshop antibodies have been used to investigate lymphocyte populations in the normal dog and in a range of diseases from lymphocytic neoplasms through conditions with an immune-mediated component such as Leishmaniasis to potentially autoimmune disorders such as rheumatoid arthritis and chronic superficial keratitis.
机译：犬白细胞抗原工作坊（CLAW）的建立是为了生产和流通针对定义狗中特定白细胞类型的细胞表面分子的单克隆抗体。该研讨会产生的抗体已用于犬免疫系统的研究。尽管已经证明了狗与其他动物之间的许多相似之处，但车间研究发现了该物种的一些异常情况：例如CD4抗原不仅在辅助/诱导性T淋巴细胞上表达，而且在犬中性粒细胞上也以高密度表达。车间抗体已用于研究正常犬和多种疾病中的淋巴细胞种群，从淋巴细胞性肿瘤到具有免疫介导成分（如利什曼病）的条件，再到潜在的自身免疫性疾病如类风湿性关节炎和慢性浅表性角膜炎。

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