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首页> 外文期刊>The Veterinary Journal >VIRAL PROTEINS OF BOVINE PAPILLOMAVIRUS TYPE 4 DURING THE DEVELOPMENT OF ALIMENTARY CANAL TUMOURS
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VIRAL PROTEINS OF BOVINE PAPILLOMAVIRUS TYPE 4 DURING THE DEVELOPMENT OF ALIMENTARY CANAL TUMOURS

机译：消化道肿瘤发展过程中4型牛乳头瘤病毒的病毒蛋白

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摘要

In cattle infection of the upper alimentary canal mucosa by bovine papillomavirus type 4 (BPV-4) results in the development of papillomas which can progress to cancer in animals fed on bracken fern. This paper describes a study of the cellular and subcellular distribution of a number of different BPV-4 products in experimentally-induced BPV-4 tumours. E8 and E4 proteins were detected solely as cytoplasmic antigens in the undifferentiated and differentiated layers of the papilloma, respectively; L2 was detected solely as a nuclear antigen in the differentiated layers, whereas E7 was present in either the nucleus or the cytoplasm depending on the differentiation stage of the keratinocyte. Replicative forms of viral DNA were detected from the spinous to the squamous layers. Viral antigens were not detected during papilloma regression or in carcinomas. E8 was most prominent in early developmental stages, while E4 and L2 were most abundant in mature papillomas, E7 was present in large amounts in both early and mature stages, declining at later stages. These results suggest a temporal and spatial requirement for the expression and function of the viral proteins.
机译：在牛中，牛乳头瘤病毒4型（BPV-4）感染了上消化道粘膜，导致乳头状瘤的发展，在以蕨类植物为食的动物中，乳头状瘤可发展为癌症。本文描述了在实验诱导的BPV-4肿瘤中许多不同BPV-4产物在细胞和亚细胞中分布的研究。 E8和E4蛋白分别在乳头状瘤的未分化层和分化层中仅作为细胞质抗原被检测到; L2仅在分化层中被检测为核抗原，而E7则存在于细胞核或细胞质中，具体取决于角质形成细胞的分化阶段。从棘突层到鳞状细胞层均检测到病毒DNA的复制形式。在乳头状瘤消退期间或癌中未检测到病毒抗原。 E8在发育早期最为突出，而E4和L2在成熟的乳头状瘤中最为丰富，E7在早期和成熟阶段均大量存在，而在后期则下降。这些结果提示了病毒蛋白表达和功能的时间和空间要求。

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