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首页> 外文期刊>The Veterinary Journal >COMPARISON OF CARPROFEN AND FLUNIXIN MEGLUMINE AS ADJUNCTIVE THERAPY IN BOVINE RESPIRATORY DISEASE
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COMPARISON OF CARPROFEN AND FLUNIXIN MEGLUMINE AS ADJUNCTIVE THERAPY IN BOVINE RESPIRATORY DISEASE

机译：比较卡洛芬和氟苯丙胺葡聚糖作为牛呼吸系统疾病辅助治疗的方法

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摘要

In an open, controlled, multi-centre clinical field trial, seven 'naturally occurring' outbreaks of acute febrile (rectal temperature greater than or equal to 39.5 degrees C) respiratory disease in housed calves were treated with a single antimicrobial agent, and either the non-steroidal anti-inflammatory drug (NSAID) carprofen (n=95) or flunixin meglumine (n=92) on an alternate basis. Carprofen was administered as a single subcutaneous injection at a mean dosage of 1.4 mg kg(-1) (range 1.2 to 1.9 mg kg(-1)) body weight on the first day and flunixin meglumine by intravenous injection at a mean dosage of 2.0 mg kg(-1) (range 1.2 to 2.6 mg kg(-1)) body weight on the first 3 consecutive days. All calves were examined clinically immediately prior to initial treatment and on three occasions up to 1 week after the end of treatment. There were no statistically significant differences between NSAID groups in reduction of clinical parameters between examinations, or in overall efficacy. This trial demonstrated that a single dose of carprofen was equally effective as three daily doses of flunixin meglumine as adjunctive therapy to antimicrobial treatment in acute respiratory disease in calves.
机译：在一项开放，受控，多中心的临床野外试验中，对一种犊牛的七次“自然发生”的急性发热（直肠温度高于或等于39.5摄氏度）呼吸道疾病进行了单独的抗菌药物治疗，非甾体类抗炎药（卡洛芬（n = 95）或氟尼辛葡甲胺（n = 92））交替使用。头一天，Carprofen皮下注射平均剂量为1.4 mg kg（-1）（1.2至1.9 mg kg（-1））体重，静脉注射氟尼辛葡甲胺的平均剂量为2.0连续三天的体重kg kg（-1）（范围1.2至2.6 mg kg（-1））。在初次治疗之前立即对所有犊牛进行临床检查，并在治疗结束后直至1周内进行3次检查。在两次检查之间降低临床参数或总体疗效方面，NSAID组之间无统计学差异。该试验表明，单剂量的卡洛芬与小牛的急性呼吸道疾病的抗菌治疗的辅助治疗等效于氟尼辛葡甲胺的每日三剂。

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