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首页> 外文期刊>The Veterinary Journal >Changes in the capacity of the vagina and the compliance of the vaginalwall in ovariectomized, normal cyclical and pregnant ewes, before andafter treatment with exogenous oestradiol and progesterone
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Changes in the capacity of the vagina and the compliance of the vaginalwall in ovariectomized, normal cyclical and pregnant ewes, before andafter treatment with exogenous oestradiol and progesterone

机译：外源雌二醇和孕酮治疗前后卵巢切除，正常周期性和怀孕母羊阴道容量和阴道壁顺应性的变化

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The 'capacity' of the vagina and the compliance of the vaginal wall was measured in bilaterally ovariectomized ewes (n=7) before and after treatment with exogenous oestradiol and progesterone; in nulliparous ewes (n=7) at oestrus (Day 0) and dioestrus (Day 10) and during pregnancy, and in another group of pregnant ewes (n=15) treated with exogenous oestradiol and progesterone. Measurements were remarkably consistent within individual animals but there were considerable differences between individual animals. The vaginal capacity' and the compliance of the vaginal wall were greater at oestrus than during dioestrus. In the same seven ewes, which were studied during their first and second pregnancies, the 'capacity' of the vagina increased whereas the compliance of the vaginal wall declined; from 90 days to term both parameters remained fairly constant. For the first 2 months of gestation the vaginal capacity was greater in year 2 than year 1 but this was reversed during the last 3 months. The compliance of the vaginal wall was significantly greater (P<0.0001) in year 2 than year 1 at all stages of pregnancy. In ovariectomized ewes, progesterone only significantly increased the vaginal capacity at the highest dose rate (viz. 100 mg); the compliance of the wall was reduced at the 25 and 50 mg dose rates. Oestradiol produced an inconsistent dose response effect; whilst 5 mg and 20 mg had no effect upon the vaginal capacity, the 10 mg dose rate significantly reduced it. Similarly, the highest and lowest dose rates reduced the compliance of the vaginal wall but the 10 mg dose rate increased it. At 90 and 120 days of gestation, both 5 mg oestradiol and 100 mg progesterone increased the vaginal capacity but reduced the compliance.
机译：在用外源雌二醇和孕酮治疗前后，在双侧卵巢切除的母羊（n = 7）中测量了阴道的“容量”和阴道壁的顺应性。在发情期（第0天）和发情期（第10天）以及怀孕期间的未产母羊（n = 7），以及用外源雌二醇和孕酮治疗的另一组怀孕母羊（n = 15）。在个体动物中，测量结果非常一致，但个体动物之间存在相当大的差异。发情时的阴道容量和阴道壁的顺应性比发情时要大。在同样的七头母羊的第一次和第二次怀孕中进行研究时，阴道的“容量”增加了，而阴道壁的顺应性却下降了。从90天到任期，这两个参数保持相当恒定。在妊娠的前两个月中，第二年的阴道容量大于第一年的阴道容量，但在最近的三个月中，阴道容量有所逆转。在怀孕的所有阶段，第2年的阴道壁顺应性均明显高于第1年（P <0.0001）。在卵巢切除的母羊中，孕酮仅以最高剂量率（即100 mg）显着增加阴道容量。在25和50 mg剂量时，壁的顺应性降低。雌二醇产生不一致的剂量反应作用。 5 mg和20 mg对阴道容量没有影响，而10 mg剂量率则明显降低了阴道容量。同样，最高和最低剂量率会降低阴道壁的顺应性，但10 mg剂量率会增加其顺应性。在妊娠90天和120天时，5 mg雌二醇和100 mg孕酮均增加了阴道容量，但降低了依从性。

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