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Scintigraphical evaluation of alveolar clearance in horses

机译：马的肺泡清除率的闪烁扫描仪

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摘要

This study proposed a standardized method for measuring alveolar epithelium membrane permeability in the horse. The normal rate of clearance (%.min(-1)) from lung into blood of nebulized Tc-99m-DTPA has been established for healthy horses (Group A) compared with values obtained with horses suffering from chronic obstructive pulmonary disease (COPD; Group B). The Tc-99m-DTPA clearance was measured in the caudoventral (R-1) and in the half caudal (R-2) parts of the left lung during different time intervals. The two regions aimed to define the influence of the airways on measured clearance (R-2 contained proportionally more conducting airways than R-1). It was concluded that a comparison of groups of subjects may be performed in R-2 and on data collected during a 20 min period. The normal clearance rate in R-2 was 1.80+/-0.46%.min(-1) (T-1/2R2=40.99+/-12.45 min) in Group A. In Group B, a significantly faster Tc-99m-DTPA transfer rate was found (4.17+/-0.83%.min(-1) or T-1/2R2=17.17+/-3.38 min). Bronchoalveolar lavage (BAL) suggested that the increased permeability measured in Group B could be the result of lung inflammatory responses.
机译：这项研究提出了一种用于测量马的肺泡上皮膜通透性的标准化方法。已为健康马匹（A组）确定了正常人从肺到雾化的Tc-99m-DTPA雾中的血液清除率（％.min（-1）），与患有慢性阻塞性肺病（COPD; B组）。在不同的时间间隔内，在左肺的假腹（R-1）和尾半部（R-2）中测量了Tc-99m-DTPA清除率。这两个区域旨在确定气道对测得间隙的影响（R-2比R-1成比例地包含更多的传导气道）。结论是，可以在20分钟内对R-2受试者和收集的数据进行比较。 A组的R-2正常清除率为1.80 +/- 0.46％.min（-1）（T-1 / 2R2 = 40.99 +/- 12.45 min）。B组的Tc-99m-发现DTPA转移速率（4.17 +/- 0.83％.min（-1）或T-1 / 2R2 = 17.17 +/- 3.38分钟）。支气管肺泡灌洗（BAL）表明，B组中测得的通透性增加可能是肺部炎症反应的结果。

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