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首页> 外文期刊>The Veterinary Journal >Induced diarrhoea in horses part 2: Response to administration of an oralrehydration solution
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Induced diarrhoea in horses part 2: Response to administration of an oralrehydration solution

机译：马诱发的腹泻第2部分：口服补液的反应

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摘要

Hydration status, electrolyte balance and acid-base balance were studied in four adult standardbred geldings with castor oil-induced diarrhoea. The horses received an oral rehydration solution (ORS) at a point when signs consistent with mild decreases in effective circulating fluid volume were first detected. within 1.5 h of ORS administration, all horses exhibited a significant metabolic acidosis. At this time, mean values for venous blood pH, [HCO3], and standard base excess were 7.264+/-0.011, 17.7+/-0.3 mmol L-1, and -8.2+/-0.4 mmol L-1, respectively. Throughout the duration of the study, plasma volume did not change significantly, despite a decreasing trend, which tended to recover towards normal values 8 h after administration of the ORS. Signs of abdominal discomfort were observed in all horses following the last of three doses of ORS (8-10 L) administered at 30 min intervals. Faecal fluid sodium concentration increased significantly with diarrhoea, and reached values fourfold those in normal horses, while faecal dry matter sodium concentration increased exponentially following the onset of clinical signs. Despite this increase in sodium concentration, faecal fluid remained hypotonic at all stages. Our findings suggest that, while ORS can help restore systemic fluid balance, several factors influence their effectiveness. Two likely factors identified in this study were the ionic composition of the ORS as well as the rate of administration. We concluded that the electrolyte composition of current ORS may not be ideal to treat diarrhoea in horses and that administration of 8-10 L, of ORS every 30 min via nasogastric tube may result in too rapid small intestinal transit to allow sufficient time for absorption.
机译：研究了蓖麻油引起的腹泻的四种成年标准br鱼的水合状态，电解质平衡和酸碱平衡。在首次检测到与有效循环液量轻度下降相符的迹象时，这些马匹接受了口服补液（ORS）。在ORS给药后1.5小时内，所有马匹均出现明显的代谢性酸中毒。此时，静脉血pH，[HCO3]和标准碱过量的平均值分别为7.264 +/- 0.011、17.7 +/- 0.3 mmol L-1和-8.2 +/- 0.4 mmol L-1。在整个研究过程中，尽管血浆量呈下降趋势，但血浆量并未发生明显变化，在口服ORS后8小时，血浆量趋于恢复至正常值。在每30分钟间隔服用三剂ORS（8-10 L）后，在所有马匹中均观察到腹部不适的迹象。腹泻时粪便液钠浓度显着增加，达到正常马匹的四倍，而随临床症状的发作，粪便干物质钠浓度呈指数增加。尽管钠浓度有所增加，但粪便液在所有阶段均保持低渗。我们的发现表明，尽管ORS可以帮助恢复体液平衡，但有几个因素会影响其有效性。在这项研究中确定的两个可能的因素是ORS的离子组成以及给药速率。我们得出的结论是，目前的ORS电解质成分可能不是治疗马腹泻的理想方法，并且每隔30分钟通过鼻胃管给药8-10升ORS可能会导致小肠运输速度过快，以至于没有足够的吸收时间。

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