首页> 外文期刊>The Veterinary Journal >Equine herpesviruses 1 (EHV-1) and 4 (EHV-4) - epidemiology, disease and immunoprophylaxis: A brief review
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Equine herpesviruses 1 (EHV-1) and 4 (EHV-4) - epidemiology, disease and immunoprophylaxis: A brief review

机译:马疱疹病毒1(EHV-1)和4(EHV-4)-流行病学,疾病和免疫预防:简要回顾

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This review concentrates on the epidemiology, latency and pathogenesis of, and the approaches taken to control infection of horses by equine herpesvirus types 1 (EHV-1) and 4 (EHV-4). Although both viruses may cause febrile rhinopneumonitis, EHV-1 is the main cause of abortions, paresis and neonatal foal deaths. The lesion central to these three conditions is necrotising vasculitis and thrombosis resulting from lytic infection of endothelial cells lining blood capillaries. The initiation of infection in these lesions is likely to be by reactivated EHV-1 from latently infected leukocytes. However, host factors responsible for reactivation remain poorly understood. While vaccine development against these important viruses of equines involving classical and modern approaches has been ongoing for over five decades, progress, compared to other alpha herpesviruses of veterinary importance affecting cattle and pigs, has been slow. However recent data with a live temperature sensitive EHV-1 vaccine show promise.
机译:这篇综述集中在马的疱疹病毒1型(EHV-1)和4型(EHV-4)的流行病学,潜伏期和发病机理,以及控制马感染的方法。尽管两种病毒都可能引起高热性鼻肺炎,但EHV-1是流产,轻瘫和新生儿驹死亡的主要原因。这三种情况的中心病变是坏死性血管炎和血栓形成,这是由于溶血在血管毛细血管内的内皮细胞溶解性感染所致。这些病变中感染的开始很可能是由潜伏感染的白细胞中重新激活的EHV-1引起的。然而,负责重新激活的宿主因素仍然知之甚少。尽管针对涉及经典和现代方法的这些重要马病毒的疫苗开发已经持续进行了五十多年,但与其他具有重要影响力的牛和猪的兽用α疱疹病毒相比,进展仍然缓慢。但是,最近的一项对温度敏感的EHV-1活疫苗的数据显示出了希望。

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