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首页> 外文期刊>The Veterinary Journal >Distribution of new methylene blue injected into the caudal epidural space in cattle
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Distribution of new methylene blue injected into the caudal epidural space in cattle

机译：牛尾硬膜外腔注射新亚甲蓝的分布

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摘要

To investigate the distribution of solutions injected into the first intercoccygeal epidural space, 24 adult, standing cattle were randomly assigned to 5-, 10- and 20-mL groups and injected with 0.12% new methylene blue (NMB) in 0.9% saline. Ten heifers received 1 mL NMB solution/100 kg of body weight. There was a significant correlation between the injected volume and the number of cranially stained spinal segments in three adult cattle groups (correlation coefficient R2=0.46; P<0.0001). In three cattle, NMB solution did not distribute more than one spinal segment cranially from the injection site due either to fibrosis of the epidural tissue or to inadvertent intravenous administration into the epidural vein. The study showed that the larger the volume of solution injected, the greater the spread with increased individual variation. The results could form the basis for determining the volume of injection required and for evaluating the pharmacokinetics of anaesthetics used in caudal epidural anaesthesia.
机译：为了调查注射到第一个球尾壁硬膜外腔中的溶液的分布，将24只成年站立的牛随机分为5、10和20 mL组，并注射0.92％盐水中的0.12％新亚甲基蓝（NMB）。十头小母牛接受1毫升NMB溶液/ 100千克体重。在三个成年牛组中，注射量与颅骨染色的脊髓节段数量之间存在显着相关性（相关系数R2 = 0.46; P <0.0001）。在三头牛中，由于硬膜外组织的纤维化或硬膜外静脉内无意的静脉内给药，NMB溶液从注射部位的颅骨不分布一个以上的脊髓节段。研究表明，注入的溶液量越大，散布越大，个体差异越大。结果可为确定所需注射量和评估用于尾硬膜外麻醉的麻醉药的药代动力学奠定基础。

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