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首页> 外文期刊>The Veterinary Journal >Rhodococcus equi pneumonia in foals: An assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice
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Rhodococcus equi pneumonia in foals: An assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice

机译：小马驹中的红血球菌性肺炎：在马临床实践中评估血清淀粉样蛋白A和血浆纤维蛋白原浓度的早期诊断价值

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摘要

Early diagnosis and prevention of Rhodococctts equi pneumonia in foals represent important goals for equine clinicians. Recent protocols for diagnosis and treatment of Rhodococcosis in foals typically rely on a multimodal approach based on sonographic evidence suggestive of pyogranulomas, sonographic abscess scores and laboratory findings including plasma fibrinogen concentrations, blood biochemistry testing and platelet and leukocyte counts. The aim of this study was to assess the utility of weekly testing of serum amyloid A (SAA) and plasma fibrinogen concentrations in foals to achieve early diagnosis of R. equi pneumonia prior to the onset of clinical signs. This testing was used to simulate a clinically practical screening procedure and compared with thoracic ultrasonography performed in parallel. The present study suggests that SAA does not represent a reliable early marker of Rhodococcosis when plasma concentrations are tested weekly. However, when clinical signs of R. equi pneumonia are present, SAA concentrations may allow clinicians to obtain 'real-time' indications concerning both the progress of infection and the effectiveness of therapy. This study raises the possibility that plasma fibrinogen monitoring starting at 1 week of age and repeated on a weekly basis, could serve as a screening test allowing clinicians to identify foals as suspected of R. equi infection. Future investigations regarding both physiological plasma fibrinogen concentrations in foals as well as fibrinogen kinetics in foals affected with R. equi pneumonia, including the establishment of appropriate reference intervals for the test method employed in this study, will be necessary in order to clarify this possibility. (C) 2014 Elsevier Ltd. All rights reserved.
机译：对小马驹的红球菌肺炎的早期诊断和预防是马临床医生的重要目标。驹的红球菌病的诊断和治疗的最新方案通常依赖于一种多峰方法，该方法基于提示肾盂肉芽肿的超声证据，超声脓肿评分和实验室检查结果，包括血浆纤维蛋白原浓度，血液生化测试以及血小板和白细胞计数。这项研究的目的是评估小马驹每周检测血清淀粉样蛋白A（SAA）和血浆纤维蛋白原浓度的效用，以在临床体征发作之前及早诊断马鞭毛性肺炎。该测试用于模拟临床实用的筛查程序，并与并行进行的胸腔超声检查相比较。本研究表明，当每周检测血浆浓度时，SAA不能代表红球菌病的可靠早期标记。但是，当出现马鞭毛状肺炎的临床体征时，SAA浓度可以使临床医生获得有关感染进程和治疗效果的“实时”指征。这项研究提出了一种可能性，即从1周龄开始并每周重复一次进行血浆纤维蛋白原监测，可以作为一项筛查测试，使临床医生可以识别出怀疑是马驹感染马驹的小马驹。为了阐明这种可能性，有必要对小马驹中的生理血浆纤维蛋白原浓度以及受马鞭毛性肺炎影响的小马驹中的纤维蛋白原动力学进行进一步研究，包括为此研究中使用的测试方法建立适当的参考区间。 （C）2014 Elsevier Ltd.保留所有权利。

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