There is little available evidence to demonstrate how cough strength mediates the risk of aspiration-related pneumonia in acute stroke. Our secondary analysis of trial data indicates that risk of pneumonia reduces with increasing peak cough flow (PCF) of voluntary cough (OR 0.994 for each 1 L/min increase in PCF, 95% CI 0.988 to 1.0, p=0.035); and to a lesser degree with increasing PCF of reflex cough (OR 0.998 for each 1 L/min increase in PCF, 95% CI 0.992 to 1.004, p=0.475). These data serve hypothesis generation. Further studies are needed to confirm these findings and validate their clinical utility.
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机译：几乎没有可用的证据来证明咳嗽强度如何介导急性中风与吸入性肺炎的风险。我们对试验数据的二次分析表明，随着自愿性咳嗽的峰值咳嗽流量（PCF）的增加，肺炎的风险降低（PCF每增加1 L / min，OR为0.994，95％CI为0.988至1.0，p = 0.035）;并随着反射性咳嗽PCF的增加而降低（PCF每增加1 L / min，OR为0.998，95％CI为0.992至1.004，p = 0.475）。这些数据有助于假设的产生。需要进一步的研究以确认这些发现并验证其临床实用性。
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