...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype.
【24h】

Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype.

机译：肿瘤坏死因子α变异与CF肺表型的关联。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The pulmonary phenotype in patients with cystic fibrosis (CF), even in those with the same CF transmembrane conductance regulator (CFTR) genotype, is variable and must therefore be influenced by secondary genetic factors as well as environmental factors. Possible candidate genes that modulate the CF lung phenotype may include proinflammatory cytokines. One such protein is tumour necrosis factor alpha (TNFalpha), a member of the immune system. METHODS: Three polymorphic loci in the promoter (-851c/t, -308g/a, -238g/a) and one polymorphic locus in intron 1 (+691g ins/del) of the TNFalpha gene were typed by a single nucleotide primer extension assay in CF patients and healthy controls. Spirometric data and first age of infection with Pseudomonas aeruginosa were collected retrospectively from patients' medical records. RESULTS: An association was found between the TNFalpha +691g ins/del polymorphic locus and severity of CF lung disease. Patients heterozygous for +691g ins and +691g del were more likely to have better pulmonary function (mean (SD) forced expiratory volume in 1 second (FEV(1)) 79.7 (12.8)% predicted) than patients homozygous for +691g ins (mean (SD) FEV(1) 67.5 (23.0)% predicted; p = 0.008, mean difference 12.2%, 95% CI 3.5 to 21.0). Also, patients heterozygous for +691g ins and +691g del were more likely to have an older first age of infection with P aeruginosa (mean (SD) 11.4 (6.0) years) than patients homozygous for +691g ins (mean (SD) 8.3 (4.6) years; p = 0.018, mean difference 3.1 years, 95% CI 0.5 to 5.6). An association was also found with the -851c/t polymorphic locus. In the group of patients with more severe FEV(1)% predicted, a higher proportion of patients were homozygous for the -851c allele than in the other group of patients (p = 0.04, likelihood ratio chi(2), odds ratio = 2.4).Conlusion: TNFalpha polymorphisms are associated with the severity of CF lung disease in Czech and Belgian patients with CF.
机译：背景：囊性纤维化（CF）患者的肺表型，即使具有相同的CF跨膜电导调节剂（CFTR）基因型的患者，也是可变的，因此必须受到继发性遗传因素和环境因素的影响。可能调节CF肺表型的候选基因可能包括促炎细胞因子。一种这样的蛋白质是肿瘤坏死因子α（TNFalpha），它是免疫系统的成员。方法：通过单核苷酸引物延伸来确定启动子中的三个多态性基因座（-851c / t，-308g / a，-238g / a）和内含子1（+ 691g ins / del）中的一个多态性基因座。 CF患者和健康对照组进行化验。回顾性地从患者的病历中收集肺活量数据和铜绿假单胞菌感染的第一年龄。结果：TNFalpha + 691g ins / del多态性基因位点与CF肺疾病的严重程度之间存在关联。与+ 691g ins纯合的患者相比，+ 691g ins和+ 691g del杂合的患者更有可能在1秒内具有更好的肺功能（平均（SD）强迫呼气量（FEV（1））为79.7（12.8）％）（预测的平均（SD）FEV（1）为67.5（23.0）％; p = 0.008，平均差异为12.2％，95％CI为3.5至21.0）。此外，+ 691g ins和+ 691g del杂合的患者比纯合+ 691g ins（平均值（SD）8.3）的患者更容易感染铜绿假单胞菌（平均（SD）11.4（6.0）岁）。 （4.6）年; p = 0.018，平均差异3.1年，95％CI 0.5至5.6）。还发现与-851c / t多态性位点有关。在预测的FEV（1）％更严重的患者组中，-851c等位基因纯合的患者比例高于其他患者组（p = 0.04，似然比chi（2），优势比= 2.4结论：TNFα多态性与捷克和比利时CF患者的CF肺部疾病严重程度有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号