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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group.
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Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group.

机译：家庭人数，儿童感染和特应性疾病。香港仔WHEASE集团。

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BACKGROUND: This study addresses the causes of the increases in childhood asthma and allergic disease. On the basis of an observed inverse relationship between family size and allergic disease or atopy, it has been proposed that a fall in common childhood infections may have been responsible for the rise in asthma. This study was undertaken to investigate the relationships between family size and reported allergic disease and to test the hypothesis that an inverse relationship between the two is a consequence of childhood infections. METHODS: Data had been obtained in a 1964 cross sectional survey of a random sample of Aberdeen schoolchildren aged between 10 and 14 in that year. Records of the presence or absence of asthma, eczema, or hay fever at the time of the survey and a history of measles, pertussis, varicella, rubella, and mumps before and after the age of three years were available for 2111 subjects. RESULTS: The risks of hay fever (odds ratio 0.2, 95% CI 0.1 to 0.8) and eczema (OR 0.3, CI 0.1 to 0.7) were inversely related to having had three or more older siblings, whilst the risk of asthma (OR 0.4, CI 0.1 to 0.9) was inversely related to having had three or more younger siblings. Increasing total numbers of siblings showed a significant trend in protection against both eczema and hay fever. A weak protective effect against asthma was found for measles after the age of three (OR 0.5, CI 0.3 to 0.9) and slight increases in the risk of eczema were associated with having had rubella or pertussis and of asthma with having had varicella. The number of infections before the age of three was associated with a significant trend in the odds ratios towards increased risk of asthma (p = 0.025). There were significant trends in the odds ratios towards greater risk of eczema and hay fever with increasing exposure to rubella, mumps, and varicella. These relations between infection and atopic diseases were independent of the potential confounding factors age, sex, father's social class, and total number of siblings. CONCLUSIONS: These data add to the accumulating evidence that membership of a large sibship confers some protection against atopic disease. This does not appear to be explained by the common childhood infections which show conflicting relationships with atopic disease, in that measles may have some protective effect against asthma but the more infections a child has had, the more likely he or she is to have atopic disease. The explanation of the sibship effect is likely to lie elsewhere and the fall in common childhood infections is unlikely to explain the rise in atopic disease.
机译：背景：这项研究解决了儿童哮喘和过敏性疾病增加的原因。根据观察到的家庭规模与过敏性疾病或特应性之间的反比关系，有人提出，儿童期常见感染的减少可能是哮喘上升的原因。这项研究的目的是调查家庭人数与报告的过敏性疾病之间的关系，并检验以下假设：两者之间的反向关系是儿童感染的结果。方法：数据是在1964年的横断面调查中获得的，该调查是该年10到14岁之间的阿伯丁小学生的随机样本。 2111名受试者可在调查时记录是否存在哮喘，湿疹或花粉症，以及3岁前后麻疹，百日咳，水痘，风疹和腮腺炎的病史。结果：花粉症（奇数比为0.2，95％CI为0.1至0.8）和湿疹（OR为0.3，CI为0.1至0.7）的风险与三个或更多个同龄兄弟姐妹呈负相关，而哮喘的风险（OR为0.4） ，CI为0.1到0.9）与三个或三个以上年轻的兄弟姐妹成反比。兄弟姐妹总数的增加显示出针对湿疹和花粉症的保护作用的显着趋势。三岁后（OR 0.5，CI 0.3至0.9）对麻疹的保护作用较弱，患有风疹或百日咳的湿疹风险略有增加，患有水痘的哮喘患者。三岁之前的感染次数与哮喘风险增加的几率显着相关（p = 0.025）。随着暴露于风疹，腮腺炎和水痘的风险增加，比值比有明显的趋势，具有更大的湿疹和花粉热风险。感染和特应性疾病之间的这些关系与年龄，性别，父亲的社会阶层和兄弟姐妹总数的潜在混杂因素无关。结论：这些数据增加了越来越多的证据，表明大同胞的成员赋予了一些预防特应性疾病的保护。这似乎不能用常见的儿童期感染来解释，这种感染表明与特应性疾病之间存在相互矛盾的关系，因为麻疹可能对哮喘具有一定的保护作用，但是儿童感染的次数越多，他或她患特应性疾病的可能性就越大。 。有关同胞影响的解释可能在其他地方，儿童期常见感染的减少不太可能解释特应性疾病的增加。

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