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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Development and validation of database indexes of asthma severity and control.
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Development and validation of database indexes of asthma severity and control.

机译：哮喘严重程度和控制的数据库指标的开发和验证。

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BACKGROUND: The use of administrative databases to perform epidemiological studies in asthma has increased in recent years. The absence of clinical parameters to measure the level of asthma severity and control is a major limitation of database studies. A study was undertaken to develop and validate two database indexes to measure the control and severity of asthma. METHODS: Database indexes of asthma severity and control were derived from definitions in the Canadian Asthma Consensus Guidelines based on dispensed prescriptions and on medical services recorded in two large administrative databases from the Canadian province of Quebec (Regie de l'Assurance Maladie du Quebec (RAMQ) and MED-ECHO) over 12 months. The database indexes of asthma severity and control were validated against the pulmonary function test results of 71 patients with asthma randomly selected from two asthma clinics, and they were also applied to a cohort of patients with asthma followed up for 139 283 person-years selected from the RAMQ and MED-ECHO databases between 1 January 1997 and 31 December 2004. RESULTS: According to the database indexes, 49.3%, 29.6% and 21.1% of patients recruited at the asthma clinics were found to have mild, moderate and severe asthma, respectively, while 53.5% were found to have controlled asthma. The mean predicted value of the forced expiratory volume in 1 s (FEV(1)) ranged from 89.8% for mild asthma to 61.5% for severe asthma (p<0.001), whereas the range from controlled to uncontrolled asthma was 89.5% to 67.3% (p<0.001). The ratio of the FEV(1) to the forced vital capacity (FEV(1)/FVC ratio) measured in 56 patients ranged from 75.8% for mild asthma to 61.8% for severe asthma (p = 0.030), whereas the range from controlled to uncontrolled asthma was 75.3% to 65.7% (p<0.001). CONCLUSION: In the absence of clinical data, these database indexes could be used in epidemiological studies to assess the severity and control of asthma.
机译：背景：近年来，使用管理数据库进行哮喘流行病学研究的人数有所增加。缺乏临床指标来衡量哮喘严重程度和控制水平是数据库研究的主要局限。进行了一项研究以开发和验证两个数据库指标，以衡量哮喘的控制和严重程度。方法：哮喘严重程度和控制的数据库指标来自《加拿大哮喘共识指南》中的定义，该指南基于已分发的处方以及在加拿大魁北克省两个大型行政数据库中记录的医疗服务（Regie de l'Assurance Maladie du Quebec（RAMQ ）和MED-ECHO）超过12个月。根据从两家哮喘诊所随机选择的71例哮喘患者的肺功能测试结果验证了哮喘严重程度和控制的数据库指标，并将其应用于一组随访的139283人年的哮喘患者中结果：在1997年1月1日至2004年12月31日之间的RAMQ和MED-ECHO数据库中。结果：根据数据库索引，发现在哮喘诊所招募的患者中有49.3％，29.6％和21.1％患有轻度，中度和重度哮喘，分别有53.5％的人控制了哮喘。 1 s（FEV（1））在1 s内的强制呼气量的平均预测值范围从轻度哮喘的89.8％到重度哮喘的61.5％（p <0.001），而从控制到不受控制的哮喘的范围是89.5％到67.3 ％（p ＜0.001）。在56例患者中测得的FEV（1）与强制肺活量之比（FEV（1）/ FVC比）范围从轻度哮喘的75.8％到重度哮喘的61.8％（p = 0.030），而在控制范围内不受控制的哮喘患病率为75.3％至65.7％（p <0.001）。结论：在缺乏临床数据的情况下，这些数据库索引可用于流行病学研究以评估哮喘的严重程度和控制。

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