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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Bronchoscopic findings in children with non-cystic fibrosis chronic suppurative lung disease.
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Bronchoscopic findings in children with non-cystic fibrosis chronic suppurative lung disease.

机译：小儿非囊性纤维化慢性化脓性肺疾病的支气管镜检查结果。

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BACKGROUND: Published data on the frequency and types of flexible bronchoscopic airway appearances in children with non-cystic fibrosis bronchiectasis and chronic suppurative lung disease are unavailable. The aims of this study were to describe airway appearances and frequency of airway abnormalities and to relate these airway abnormalities to chest high resolution computed tomography (cHRCT) findings in a cohort of children with non-cystic fibrosis chronic suppurative lung disease (CSLD). METHODS: Indigenous children with non-cystic fibrosis CSLD (>4 months moist and/or productive cough) were prospectively identified and collected over a 2.5 year period at two paediatric centres. Their medical charts and bronchoscopic notes were retrospectively reviewed. RESULTS: In all but one child the aetiology of the bronchiectasis was presumed to be following a respiratory infection. Thirty three of the 65 children with CSLD underwent bronchoscopy and five major types of airway findings were identified (mucosal abnormality/inflammation only, bronchomalacia, obliterative-like lesion, malacia/obliterative-like combination, and no macroscopic abnormality). The obliterative-like lesion, previously undescribed, was present in 16.7% of bronchiectatic lobes. Structural airway lesions (bronchomalacia and/or obliterative-like lesion) were present in 39.7% of children. These lesions, when present, corresponded to the site of abnormality on the cHRCT scan. CONCLUSIONS: Structural airway abnormality is commonly found in children with post-infectious bronchiectasis and a new bronchoscopic finding has been described. Airway abnormalities, when present, related to the same lobe abnormality on the cHRCT scan. How these airway abnormalities relate to aetiology, management strategy, and prognosis is unknown.
机译：背景：尚无关于非囊性纤维化支气管扩张和慢性化脓性肺病患儿的柔性支气管镜气道出现频率和类型的公开数据。这项研究的目的是描述一组非囊性纤维化慢性化脓性肺病（CSLD）儿童的气道外观和气道异常频率，并将这些气道异常与胸部高分辨率计算机断层扫描（cHRCT）结果相关联。方法：前瞻性鉴定并在两个儿科中心收集了为期2.5年的非囊性纤维化CSLD（> 4个月湿润和/或生产性咳嗽）的儿童。他们的病历和支气管镜记录进行了回顾性审查。结果：除一名儿童外，所有患儿的支气管扩张病因被认为是呼吸道感染。在65名CSLD儿童中，有33名接受了支气管镜检查，发现了五种主要的气道检查结果（仅粘膜异常/发炎，支气管软化，闭塞性病变，软化/闭塞性合并，无宏观异常）。 16.7％的支气管肺叶中存在先前未描述的闭塞样病变。 39.7％的儿童存在结构性气道病变（支气管软化和/或闭塞样病变）。这些病变（如果存在）对应于cHRCT扫描的异常部位。结论：结构性气道异常常见于感染后的支气管扩张患儿，并描述了一种新的支气管镜检查结果。如果存在气道异常，则与cHRCT扫描中的同一叶异常有关。这些气道异常与病因，治疗策略和预后的关系尚不清楚。

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