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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma.
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Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma.

机译：儿童季节性过敏性哮喘中草花粉暴露，症状和呼出气一氧化氮的纵向研究。

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摘要

BACKGROUND: Exhaled nitric oxide (NO) has been proposed as a marker of airway eosinophilic inflammation in asthma. There is currently a paucity of longitudinal data relating it to allergen exposure and asthma symptoms. METHODS: Forty four children (6-16 years) with seasonal allergic asthma were sequentially followed before and during the grass pollen season. Asthma symptoms, lung function, NO levels, and pollen counts were recorded. The relationship between exhaled NO and both the pollen levels and asthma control were assessed longitudinally, comparing a subject's measurements with their previous ones. RESULTS: The median exhaled NO concentration was significantly increased during the pollen season (6.2 v 9.2 parts per billion (ppb), p<0.002; median change 2.9 ppb, 95% confidence interval 1.5 to 5.4). Exhaled NO was best associated with the mean pollen count in the week before measurement. It was also significantly associated with asthma control. CONCLUSIONS: The results suggest that, within a longitudinal model, the exhaled NO concentration is related to preceding allergen exposure and asthma control. It may be clinically more useful to compare exhaled NO values with a subject's previous values than to compare them with a population based normal range.
机译：背景：呼出气一氧化氮（NO）已被提议作为哮喘气道嗜酸性粒细胞炎症的标志。当前缺乏与过敏原暴露和哮喘症状相关的纵向数据。方法：在草花粉季节之前和期间，依次随访了44名6至16岁的季节性过敏性哮喘患儿。记录哮喘症状，肺功能，NO水平和花粉计数。纵向评估呼出的NO与花粉水平和哮喘控制之间的关系，将受试者的测量值与其以前的测量值进行比较。结果：在花粉季节中，呼出的NO浓度中位数显着增加（6.2 v 9.2十亿分之一（ppb），p <0.002;中位数变化2.9 ppb，95％置信区间1.5至5.4）。测量前一周呼出的NO与平均花粉数最相关。它也与哮喘控制显着相关。结论：结果表明，在纵向模型中，呼出的NO浓度与先前的过敏原暴露和哮喘控制有关。将呼出的NO值与受试者的先前值进行比较在临床上比将其与基于人群的正常范围进行比较可能更有用。

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