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首页> 外文期刊>Therapeutic hypothermia and temperature management >Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice: In recent months we have had three patients who have exhibited seizure activity (on the EEG) during the chilling process. All three of these patients had poor outcomes and ultimately expired. Has anyone had a patient with seizure activity during chilling who survived and had a full recovery?
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Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice: In recent months we have had three patients who have exhibited seizure activity (on the EEG) during the chilling process. All three of these patients had poor outcomes and ultimately expired. Has anyone had a patient with seizure activity during chilling who survived and had a full recovery?

机译:临床问答:将治疗温度管理从理论转变为实践:最近几个月,我们有3名患者在冷冻过程中表现出癫痫发作(在EEG上)。所有这三例患者的预后均较差,并最终死亡。有没有人在寒冷期间有癫痫发作的患者幸存并完全康复?

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Seizure activity has long been associated with poor outcome after cardiac arrest. With the advent of therapeutic hypothermia after cardiac arrest (TH) and the use of continuous EEG (cEEG) during cooling, there is growing interest in using cEEG to predict outcome. Seizure activity and epilepiform discharges are still identified as risk factors that may be directly related to poor outcome; however, recent studies identified other EEG patterns that may predict both good and poor outcome. EEG reactivity, a term used to describe an alteration in the amplitude and waveform of EEG activity in response to stimuli, seems to play role in this prediction. Rosetti et al. (2010) described this reactivity pattern in TH patients. All survivors with cEEG demonstrating background reactivity had favorable outcome compared to those with a nonreactive cEEG background. A pattern of prolonged nonreactive discontinuous burst suppression was associated with mortality in 100% of the cases. EEG patterns demonstrating generalized slow wave activity and continuous cEEG patterns correlate with survival and better prognosis compared to isoelectric or low-voltage electroencephalograms that predict poor outcome (Kawai, 2011; Rundgren et al., 2012). Outcome data showing improvement of outcome after aggressive treatment of status epilepticus are not yet available but are also recommended as a way to improve outcome based on clinical experiences of practitioners who have witnessed individual episodes of good recovery (Blondin, 2011).
机译:长期以来,癫痫发作与心脏骤停后不良结局有关。随着心脏骤停后治疗性体温过低(TH)的出现以及冷却期间使用连续性EEG(cEEG),人们越来越关注使用cEEG预测结局。癫痫活动和癫痫样放电仍被认为是可能与不良预后直接相关的危险因素。然而,最近的研究发现了其他脑电图模式,可以预测预后好坏。脑电反应性,用于描述脑电活动响应于刺激的幅度和波形变化的术语,似乎在该预测中起作用。 Rosetti等。 (2010)描述了TH患者的这种反应模式。与具有非反应性cEEG背景的患者相比,所有具有cEEG表现出背景反应性的幸存者均具有良好的预后。延长的非反应性不连续爆发抑制的模式与100%的病例的死亡率相关。与等电或低压脑电图预测的预后较差相比,脑电图模式显示出普遍的慢波活动和连续的cEEG模式与生存率和更好的预后相关(Kawai,2011; Rundgren等,2012)。目前尚无显示积极治疗癫痫持续状态后结果改善的结果数据,但也建议根据目击者个体康复情况良好的临床经验将其作为改善结果的一种方法(Blondin,2011)。

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