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Structure-function associations in hippocampus in bipolar disorder

机译：双相情感障碍海马结构与功能的关联

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Hippocampus volume decreases and verbal memory deficits have been reported in bipolar disorder (BD) as independent observations. We investigated potential associations between these deficits in subjects with BD. Hippocampus volumes were measured on magnetic resonance images of 31 subjects with BD and 32 healthy comparison (HC) subjects. The California Verbal Learning Test-Second Edition (CVLT) assessed verbal memory function in these subjects. Compared to the HC group, the BD group showed both significantly smaller hippocampus volumes and impaired performance on CVLT tests of immediate, short delay and long delay cued and free recall. Further, smaller hippocampus volume correlated with impaired performance in BD. Post hoc analyses revealed a trend towards improved memory in BD subjects taking antidepressant medications. These results support associations between morphological changes in hippocampus structure in BD and verbal memory impairment. They provide preliminary evidence pharmacotherapy may reverse hippocampus-related memory deficits.
机译：作为独立的观察，在双相情感障碍（BD）中报告了海马体容量减少和语言记忆障碍。我们调查了BD受试者中这些缺陷之间的潜在关联。在31位BD受试者和32位健康对照（HC）受试者的磁共振图像上测量海马体积。加州语言学习测试第二版（CVLT）评估了这些受试者的言语记忆功能。与HC组相比，BD组在立即，短时延迟和长时提示和自由召回的CVLT测试中均显示海马体积明显减小，并且表现受损。此外，较小的海马体积与BD的性能受损有关。事后分析显示，服用抗抑郁药的BD受试者记忆力有改善的趋势。这些结果支持BD海马结构的形态变化与言语记忆障碍之间的关联。他们提供了药物治疗可能逆转海马相关记忆缺陷的初步证据。

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