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首页> 外文期刊>Theriogenology >Using computational modeling to investigate sperm navigation and behavior in the female reproductive tract. (Special Issue: Special edition dedicated to European COST action FA0702 maternal interaction with gametes and embryos, GEMINI.)
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Using computational modeling to investigate sperm navigation and behavior in the female reproductive tract. (Special Issue: Special edition dedicated to European COST action FA0702 maternal interaction with gametes and embryos, GEMINI.)

机译：使用计算模型来研究女性生殖道中的精子导航和行为。 （特刊：专门版，专门介绍欧洲COST行动FA0702母体与配子和胚胎的相互作用，GEMINI。）

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摘要

The processes by which individual sperm cells navigate the length and complexity of the female reproductive tract and then reach and fertilize the oocyte is fascinating. Numerous complex processes potentially influence the transport of spermatozoa within the tract, resulting in a regulated supply of spermatozoa to the oocytes at the site of fertilization. Despite significant differences between species, breeds, and individuals, these processes converge to ensure that a sufficient number of high quality spermatozoa reach the oocytes, resulting in successful fertilization without a significant risk of polyspermy. Different factors, such as the physical complexity of the oviductal environment, changing swimming patterns, capacitation, chemotactic and thermotactic attraction, attachment and detachment from the oviductal epithelium, interactions with local oviductal secretions, individual variations in spermatozoa and subpopulations, peristaltic contractions, and the movement of fluid have all been theorized to influence the transport of spermatozoa to the site of fertilization. However, the predominance of each factor is not fully understood. Computational modeling provides a useful method for combining knowledge about the individual processes in complex systems to help understand the relative significance of each factor. The process of constructing and validating an agent-based computational model of sperm movement and transport within the oviductal environment is described in this report. Spermatozoa are modeled as individual cells with a set of behavioral rules defining how they interact with their local environment and regulate their internal state. The inclusion or potential exclusion of each factor is discussed, along with problems identifying parameters and defining behavioral rules from available literature. Finally, the benefits and limitations of the model are described.
机译：各个精子细胞通过雌性生殖道的长度和复杂性然后到达卵子并使其受精的过程令人着迷。许多复杂的过程可能会影响精子在管道中的运输，从而导致受精部位向卵母细胞的精子供应量受到调节。尽管物种，品种和个体之间存在显着差异，但这些过程仍在进行，以确保足够数量的高质量精子到达卵母细胞，从而成功进行受精而没有多精子的显着风险。不同因素，例如输卵管环境的物理复杂性，游泳方式的变化，获能，趋化和热趋向吸引，与输卵管上皮的附着和脱离，与局部输卵管分泌物的相互作用，精子和亚群的个体差异，蠕动性收缩以及从理论上讲，液体的运动都会影响精子向受精部位的转运。但是，每个因素的优势尚不完全清楚。计算建模为组合有关复杂系统中各个过程的知识提供了一种有用的方法，以帮助理解每个因素的相对重要性。本报告介绍了构建和验证输卵管环境内精子运动和运输的基于代理的计算模型的过程。精子被建模为具有一系列行为规则的单个细胞，这些行为规则定义了精子如何与其局部环境相互作用并调节其内部状态。讨论了每个因素的包含或潜在排除，以及从可用文献中识别参数和定义行为规则的问题。最后，描述了模型的好处和局限性。

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