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首页> 外文期刊>Theriogenology >Semen quality during vincristine treatment in dogs with transmissible venereal tumor.
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Semen quality during vincristine treatment in dogs with transmissible venereal tumor.

机译：长春新碱治疗可传播性病的狗的精液质量。

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The aim of this study was to evaluate the direct effects of vincristine on semen quality in dogs with transmissible venereal tumor (TVT). The semen of 17 dogs suffering from TVT during vincristine treatment was examined. Each animal received 0.6 mg,i.v. vincristine sulphate per square meter of body surface, per week for 4 wk until complete regression of the tumour. The following semen parameters were evaluated: semen volume (second fraction), sperm concentration, total spermatozoa per ejaculate, percentage of progressively motile spermatozoa, percentage of dead spermatozoa, percentage of swollen spermatozoa (hypo-osmotic swelling test) and percentage of morphologically abnormal spermatozoa (primary and secondary defects). Semen was collected andevaluated before the beginning of treatment, 3 d after each vincristine injection and 15 d after the last injection. Semen characteristics transiently deteriorated during treatment, but returned to normal 15 d later. These changes were attributed to a direct effect of vincristine on the extragonadal spermatozoal reserves contained in the epididymis and ductus deferens. A GnRH stimulation test was also performed after each semen collection in order to assess the function of the hypothalamic-pituitary-Leydig cell axis. No effect was noted on the above axis.
机译：这项研究的目的是评估长春新碱对患有可传播性病（TVT）的犬精液质量的直接影响。检查了在长春新碱治疗期间患有TVT的17只狗的精液。每只动物接受0.6mg，静脉内。每周每平方米体表硫酸长春新碱4周，直到肿瘤完全消退。评估以下精液参数：精液量（第二部分），精子浓度，每次射精的总精子，逐渐活动的精子的百分比，精子死亡的百分比，精子的肿胀（低渗溶胀试验）的百分比以及形态异常的精子的百分比（主要和次要缺陷）。在治疗开始前，每次长春新碱注射后3 d和最后一次注射后15 d收集并评估精液。治疗期间精液特征暂时恶化，但在15天后恢复正常。这些变化归因于长春新碱对附睾和输精管中所含的性腺外精子储备的直接影响。在每次收集精液后也进行了GnRH刺激试验，以评估下丘脑-垂体-Leydig细胞轴的功能。在上述轴上未发现影响。

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