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首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Factor XI and factor XII as targets for new anticoagulants
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Factor XI and factor XII as targets for new anticoagulants

机译：因子XI和因子XII作为新型抗凝剂的靶标

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Although the non-vitamin antagonist oral anticoagulants produce less intracranial bleeding than warfarin, serious bleeding still occurs. Therefore, the search for safer anticoagulants continues. Factor XII and factor XI have emerged as promising targets whose inhibition has the potential to prevent thrombosis with little or no disruption of hemostasis. Thus, thrombosis is attenuated in mice deficient in factor XII or factor XI and patients with congenital factor XII deficiency do not bleed and those with factor XI deficiency rarely have spontaneous bleeding. Strategies targeting factor XII and XI include antisense oligonucleotides to decrease their synthesis, inhibitory antibodies or aptamers, and small molecule inhibitors. These strategies attenuate thrombosis in various animal models and factor XI knockdown with an antisense oligonucleotide in patients undergoing knee replacement surgery reduced postoperative venous thromboembolism to a greater extent than enoxaparin without increasing bleeding. Therefore, current efforts are focused on evaluating the efficacy and safety of factor XII and factor XI directed anticoagulant strategies. (C) 2016 Elsevier Ltd. All rights reserved.
机译：尽管非维生素拮抗剂口服抗凝药产生的颅内出血少于华法林，但仍会发生严重的出血。因此，继续寻找更安全的抗凝剂。因子XII和因子XI已成为有希望的靶标，它们的抑制作用有可能阻止血栓形成而几乎没有止血作用。因此，在缺乏因子XII或XI的小鼠中血栓形成减弱，先天性因子XII缺乏的患者不会流血，而因子XI缺乏的患者很少有自发性出血。靶向因子XII和XI的策略包括减少其合成的反义寡核苷酸，抑制性抗体或适体以及小分子抑制剂。这些策略减轻了各种动物模型中的血栓形成，并且在进行膝关节置换手术的患者中使用反义寡核苷酸对XI因子进行了抑制，与依诺肝素相比，在不增加出血的情况下，其术后静脉血栓栓塞的程度更大。因此，当前的工作集中在评估因子XII和因子XI指导抗凝策略的有效性和安全性。 （C）2016 Elsevier Ltd.保留所有权利。

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