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首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex.
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Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex.

机译：在弹性蛋白酶切割的HCII和凝血酶-HCII复合物存在下，HCII对凝血酶的抑制作用。

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摘要

The rate of thrombin inhibition by heparin cofactor II (HCII) is facilitated by heparin or dermatan sulfate in vitro. The distributions of these glycosaminoglycans (GAGs) in vivo are not the same; heparin-like substance is rich on the surface of endothelial cells and dermatan sulfate is relatively dominant in the extravascular region. When inflammation takes place, at least two other possible existent forms of HCII, the complexed form with thrombin and the cleaved form by leukocyte elastase, are assumed to be present at relatively high concentrations in a local circumstance. We examined the interactions of HCII with the two forms of HCII on thrombin inhibition in the presence of the GAGs. By HCII in complex with thrombin or cleaved by leukocyte elastase, the affinity of HCII moiety for heparin increases and that for dermatan sulfate decreases. The two forms possibly occur at relatively high concentrations in a local pathological situation, although the heparin cofactor activity for thrombin inhibition by HCII decreases and dermatan sulfate determines the cofactor activity. These results indicate efficient thrombin inhibitory activity of HCII in the extravascular region.
机译：肝素或硫酸皮肤素可促进肝素辅因子II（HCII）对凝血酶的抑制率。这些糖胺聚糖（GAGs）在体内的分布是不一样的。肝素样物质富含于内皮细胞表面，而硫酸皮肤素在血管外区域相对占优势。当发生炎症时，假定在局部情况下存在至少两种其他可能存在的HCII形式，即与凝血酶的复合形式和被白细胞弹性蛋白酶切割的形式。我们在存在GAG的情况下检查了HCII与两种形式的HCII对凝血酶抑制的相互作用。通过HCII与凝血酶复合或被白细胞弹性蛋白酶裂解，HCII部分对肝素的亲和力增加，而对硫酸皮肤素的亲和力降低。尽管肝素辅因子抑制HCII抑制凝血酶的活性和硫酸皮肤素决定了辅因子的活性，但两种形式可能在局部病理情况下以相对较高的浓度出现。这些结果表明在血管外区域中HCII的有效凝血酶抑制活性。

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