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首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Fibrinogen fractions in the third trimester of pregnancy and in puerperium.
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Fibrinogen fractions in the third trimester of pregnancy and in puerperium.

机译：妊娠中期和产后的纤维蛋白原含量。

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摘要

The concentration of fibrinogen, its fractions, and the concentration of C-reactive protein were determined in 45 healthy pregnant women before and after vaginal (27) or caesarean section 18 delivery. The control group consisted of 33 blood donors. In pregnancy, increased concentration of total fibrinogen and its fractions and a normal concentration of C-reactive protein were noted. Three days after vaginal delivery the concentration of total and high molecular weight fibrinogen fraction decreased slightly and the ratio of high to low molecular weight fibrinogen increased. After caesarean section both total and high molecular weight fibrinogen and the ratio of high to low molecular weight fibrinogen increased. The C-reactive protein concentration increased after either type of delivery. The degree of augmentation, however, was ten times as strong after caesarean section. In all women at the end of puerperium the concentrations of the compounds studied returned to normal values. The results suggest that the mechanisms leading to the increase of fibrinogen during pregnancy and after delivery are different. The increase of all fibrinogen fractions in pregnancy may depend first of all on hormones, whereas the increased proportion of high molecular weight to low molecular weight fibrinogen after delivery depends on the acute phase reaction. The degree of this reaction depends on the type of delivery.
机译：在45名健康孕妇中，在分娩阴道（27）或剖腹产18节之前和之后确定了纤维蛋白原的浓度，其分数和C反应蛋白的浓度。对照组由33名献血者组成。在怀孕期间，注意到总纤维蛋白原及其组分的浓度增加，并且C反应蛋白的浓度正常。阴道分娩后三天，总和高分子量纤维蛋白原部分的浓度略有下降，高分子量和低分子量纤维蛋白原的比例增加。剖宫产后，总分子量和高分子量纤维蛋白原以及高分子量和低分子量纤维蛋白原的比例均增加。两种递送方式后，C反应蛋白浓度均升高。但是，剖腹产后的增强程度是其十倍。在产褥期结束的所有妇女中，所研究化合物的浓度恢复到正常值。结果表明，导致孕期和分娩后纤维蛋白原增加的机制是不同的。妊娠中所有纤维蛋白原分数的增加可能首先取决于激素，而分娩后高分子量与低分子量纤维蛋白原比例的增加取决于急性期反应。该反应的程度取决于递送的类型。

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