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首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Alpha(2)-macroglobulin levels are high in adult patients with congenital antithrombin deficiency.
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Alpha(2)-macroglobulin levels are high in adult patients with congenital antithrombin deficiency.

机译：在患有先天性抗凝血酶缺乏症的成年患者中，α（2）-巨球蛋白水平较高。

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Antithrombin is responsible for about 80% of the progressive inhibitory activity of thrombin in human plasma. The role of other protease inhibitors known to inhibit thrombin is not completely clarified. However, their contribution may become relevant when antithrombin is low. We elected to investigate adult patients with congenital antithrombin deficiency to assess the concentration of other naturally occurring thrombin inhibitors such as alpha(2)-macroglobulin, alpha(1)-antitrypsin, heparin cofactor II, and C(1)-inhibitor. The study included 59 patients with congenital antithrombin deficiency with and without a previous history of thrombosis, together with an equal number of control subjects matched for age and sex. Statistically significant differences (patients vs. controls) were observed only for alpha(2)-macroglobulin (i.e., 120 vs. 102%, p<0.01). Further analysis of antithrombin-deficient carriers with and without a past history of thrombosis showed that alpha(2)-macroglobulin levels were higher than the 90th percentile of control distribution more often in asymptomatic than symptomatic men (odds ratio=0.04; confidence interval=0.003-0.60), but not in women (odds ratio=2.14; confidence interval=0.35-13.1). In conclusion, results from this cross sectional study showed that alpha(2)-macroglobulin levels were high in patients with congenital antithrombin deficiency. Furthermore, the high levels were found more often in asymptomatic than symptomatic men. Whether this increase provides protection against thrombosis should be evaluated in a prospective study.
机译：抗凝血酶负责凝血酶在人血浆中约80％的逐步抑制活性。尚未完全阐明其他已知抑制凝血酶的蛋白酶抑制剂的作用。但是，当抗凝血酶含量低时，它们的作用可能变得很重要。我们选择调查患有先天性抗凝血酶缺乏症的成年患者，以评估其他天然存在的凝血酶抑制剂的浓度，例如α（2）-巨球蛋白，α（1）-抗胰蛋白酶，肝素辅因子II和C（1）抑制剂。该研究纳入了59名先天性抗凝血酶缺乏症患者，有无血栓形成史，以及相同数量的年龄和性别相匹配的对照组。仅对alpha（2）-巨球蛋白观察到统计学上的显着差异（患者与对照组）（即120％与102％，p <0.01）。对有和没有血栓形成史的抗凝血酶缺乏症携带者的进一步分析表明，无症状患者比有症状男性更经常出现α（2）-巨球蛋白水平高于对照分布的百分之九十（几率= 0.04;置信区间= 0.003） -0.60），但女性没有（几率= 2.14;置信区间= 0.35-13.1）。总之，这项横断面研究的结果表明，先天性抗凝血酶缺乏症患者的α（2）-巨球蛋白水平较高。此外，无症状的男性比有症状的男性更常见于高水平的男性。这种增加是否提供抗血栓形成的保护应在前瞻性研究中进行评估。

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