Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.

Yu G; LeBrun L; Gunay NS; Hoppensteadt D; Walenga JM; Fareed J; Linhardt RJ

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Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.

机译：肝素酶I作用于对应于抗凝血酶III结合位点的合成肝素五糖。

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A synthetic pentasaccharide, containing an intact antithrombin III (ATIII) binding site that is in clinical studies a specific antifactor Xa agent, serves as a substrate for a heparin lyase (heparinase I, EC 4.2.2.7) from Flavobacterium heparinum. Heparinase I, currently being assessed as a heparin reversal agent, also reverses the antifactor Xa activity of this synthetic pentasaccharide by breaking it down to inactive disaccharide and trisaccharide products.

机译：合成的五糖含有完整的抗凝血酶III（ATIII）结合位点，在临床研究中是一种特定的抗Xa因子试剂，用作肝黄素肝素裂解酶（肝素酶I，EC 4.2.2.7）的底物。肝素酶I，目前被评估为肝素逆转剂，通过将其分解为无活性的二糖和三糖产物，也逆转了该合成五糖的抗因子Xa活性。

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来源
《Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis》 |2000年第6期|共8页
作者
Yu G; LeBrun L; Gunay NS; Hoppensteadt D; Walenga JM; Fareed J; Linhardt RJ;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;神经病学;
关键词
Heparin; Heparin Lyase; Oligosaccharides; Serine Proteinase Inhibitors; IC-831423; 肝素; 肝素裂合酶; 寡糖类;

机译：Heparin;Heparin Lyase;Oligosaccharides;Serine Proteinase Inhibitors;IC-831423;肝素;肝素裂合酶;寡糖类;

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1. Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site. [J] . Yu G, LeBrun L, Gunay NS, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2000,第6期

机译：肝素酶I作用于对应于抗凝血酶III结合位点的合成肝素五糖。
2. Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin. [J] . Lormeau JC, Herault JP, Herbert JM Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 1996,第1期

机译：代表肝素与抗凝血酶结合位点的合成五糖对凝血酶VIIa-组织因子复合物的抗凝血酶介导抑制作用。
3. Quantitative analysis of antithrombin III binding site in low molecular weight heparins by exhausetive heparinases digestion and capillary electrophoresis [J] . Mingyu Zhang, Gong Li, Yi Zhang, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2017,第期

机译：辐Uperina酶消化和毛细管电泳低分子量肝素抗凝血酶III结合位点的定量分析
4. Interaction of antithrombin III-binding domain in heparins with novel heparin binding peptides [C] . Satomi Onoue, Yoshitaka Nemoto, Takahiro Mizumoto, the International Peptide Symposium . 2001

机译：肝素III结合结构域与新型肝素结合肽的抗凝血酶III结合结构域的相互作用
5. Antithrombin III residue tyrosine-131 serves as a molecular switch during heparin-mediated conformational activation of its anticoagulant activity. [D] . dela Cruz, Richard Glenn Cua. 2006

机译：抗凝血酶III残基酪氨酸131在肝素介导的抗凝活性构象活化过程中充当分子开关。
6. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin [O] . Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, 2000

机译：肝素酶对肝素中抗凝血酶III结合位点的裂解及其在低分子量肝素生成中的意义
7. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin [O] . Shriver, Zachary, Sundaram, Mallikarjun, Venkataraman, Ganesh, 2000

机译：肝素酶对肝素中抗凝血酶III结合位点的裂解及其在低分子量肝素生成中的意义
8. Methods for Preparing Low Molecular Weight Heparin with Modified Heparinase III. [R] . Liu, D., Pojasek, K., Shriver, Z., 2006

机译：用改良的肝素酶III制备低分子肝素的方法。

Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.

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