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首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Increased platelet aggregability during exercise in patients with previous myocardial infarction. Lack of inhibition by aspirin.
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Increased platelet aggregability during exercise in patients with previous myocardial infarction. Lack of inhibition by aspirin.

机译：先前有心肌梗塞的患者在运动过程中血小板聚集性增加。缺乏阿司匹林的抑制作用。

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摘要

The aim of the present study was to investigate the effects of acute exercise on platelet aggregability, blood coagulation, and fibrinolysis in patients with recent myocardial infarction, and to examine these effects in relation to two different antithrombotic regimens. Forty patients (mean age 60 years) were investigated 3 months after a myocardial infarction. They were randomized to antithrombotic treatment with either warfarin (INR 2.8-4.2) or aspirin 160 mg daily. They performed a standardized ergometer bicycle exercise test. Blood was drawn before and after the exercise. The platelet function tests included a platelet aggregate ratio (PAR), which, in the presence of aggregates, is<1. The coagulation products remained largely unchanged during the exercise, whereas the fibrinolytic activity and the catecholamine levels increased significantly. At baseline, PAR was lower in the warfarin group than in the aspirin group. During exercise, PAR was significantly reduced in both study groups (0.75 vs. 0.80), indicating increased platelet aggregability. Beta-thromboglobulin decreased in both groups. The increased platelet aggregability after exercise despite aspirin is probably due to activation by catecholamines. This implies that aspirin may have a limited antithrombotic effect during physical exercise and probably also in other situations with increased catecholamine levels.
机译：本研究的目的是研究急性运动对近期心肌梗塞患者血小板聚集性，血液凝结和纤维蛋白溶解的影响，并探讨与两种不同的抗血栓形成方案相关的影响。心肌梗塞后3个月对40名患者（平均年龄60岁）进行了调查。他们被随机分配接受抗凝治疗，每天服用华法林（INR 2.8-4.2）或阿司匹林160 mg。他们进行了标准化的测功计自行车运动测试。运动前后都抽血。血小板功能测试包括血小板聚集率（PAR），在聚集体存在时，其<1。在运动过程中，凝血产物基本保持不变，而纤溶活性和儿茶酚胺水平则显着增加。在基线时，华法林组的PAR低于阿司匹林组。在运动过程中，两个研究组的PAR均显着降低（0.75对0.80），表明血小板凝集性增加。两组中的β-血球蛋白均下降。尽管服用了阿司匹林，但运动后血小板的凝集性增加可能是由于儿茶酚胺的激活所致。这暗示阿司匹林在体育锻炼期间可能具有有限的抗血栓形成作用，并且在其他情况下儿茶酚胺水平可能也会升高。

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