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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >Elemental Concentrations in Scalp Hair, Nutritional Status and Health-Related Quality of Life in Hemodialysis Patients
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Elemental Concentrations in Scalp Hair, Nutritional Status and Health-Related Quality of Life in Hemodialysis Patients

机译：血液透析患者头皮中的元素浓度，营养状况和健康相关的生活质量

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摘要

Elemental concentrations in hair from hemodialysis (HD) patients have not been well investigated. We examined the relationships between the elemental concentrations in scalp hair and health-related quality of life (HRQOL) and nutritional status in HD patients. Twenty six elemental concentrations were measured in scalp hair samples from 60 male HD patients using inductively-coupled plasma mass spectrometry. To evaluate HRQOL, the Short Form 36 item health survey (SF36) was used. As indices of nutritional status, body mass index, serum parameters, and geriatric nutritional risk index (GNRI) were used. Phosphorus correlated positively with serum creatinine, blood urea nitrogen (BUN), GNRI and the physical domains of the SF36. Zinc correlated positively with serum creatinine, BUN and the physical domains of the SF36. Mercury and arsenic correlated positively with BUN. Cadmium correlated negatively with serum albumin, BUN and GNRI. Copper correlated positively with the physical domains of the SF36. Iodine correlated negatively with the physical domains of the SF36. Selenium correlated negatively with the mental domains of the SF36. In conclusion, phosphorus and zinc concentrations in scalp hair can be additional biomarkers of HRQOL and/or nutritional status in HD patients. Cadmium accumulation correlated with malnutrition. Iodine and selenium accumulation may adversely affect HRQOL. Further investigation is necessary to determine precisely how these elements affect these measures.
机译：血液透析（HD）患者头发中的元素浓度尚未得到很好的研究。我们检查了HD患者头皮中的元素浓度与健康相关的生活质量（HRQOL）和营养状况之间的关系。使用电感耦合等离子体质谱法测量了60名男性HD患者的头皮头发样品中的26种元素浓度。为了评估HRQOL，使用了简短的36项健康状况调查表（SF36）。作为营养状况的指标，使用了体重指数，血清参数和老年营养风险指数（GNRI）。磷与血清肌酐，血尿素氮（BUN），GNRI和SF36的物理域呈正相关。锌与血清肌酐，BUN和SF36的物理结构域呈正相关。汞和砷与BUN呈正相关。镉与血清白蛋白，BUN和GNRI呈负相关。铜与SF36的物理域呈正相关。碘与SF36的物理域呈负相关。硒与SF36的心理域呈负相关。总之，头皮头发中的磷和锌浓度可能是HD患者中HRQOL和/或营养状况的其他生物标志物。镉积累与营养不良有关。碘和硒的积累可能会对HRQOL产生不利影响。为了确定这些因素如何影响这些措施，有必要做进一步的研究。

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