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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >Impact of fibroblast growth factor 23 on lipids and atherosclerosis in hemodialysis patients.
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Impact of fibroblast growth factor 23 on lipids and atherosclerosis in hemodialysis patients.

机译：成纤维细胞生长因子23对血液透析患者脂质和动脉粥样硬化的影响。

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摘要

Levels of fibroblast growth factor (FGF) 23, a phosphatonin, are frequently elevated in patients with end-stage renal disease (ESRD) who are on maintenance hemodialysis (MHD). However, the role of FGF23 remains unclear because renal FGF receptor function might be impaired. The present cross-sectional study examines a cohort of patients (n = 196) on MHD who were not undergoing therapy with lipid-lowering drugs including sevelamer. Non-fasting venous blood samples were withdrawn before the hemodialysis (HD) session on the third day after the previous HD session to measure serum levels of albumin, calcium (Ca), phosphate (P), alkaline phosphatase, intact parathyroid hormone (PTH), total cholesterol (C), high-density lipoprotein (HDL)-C, low-density lipoprotein(LDL)-C, oxidative LDL-C, high-sensitivity C-reactive protein (HsCRP), interleukin-6 (IL-6), and FGF23. Nutritional status was assessed using the geriatric nutritional risk index (GNRI). Carotid intima-medial thickness (CIMT) was assessed using a B-mode ultrasound scanner. FGF23 was positively correlated with P, Ca(alb)xP product, and intact PTH, and inversely correlated with C and non-HDL-C. In the higher FGF23 tertile, levels of both non-HDL-C and C were significantly decreased and CIMT was less elevated compared to the lower FGF23 tertile. Multivariate analysis showed that the higher FGF23 tertile was independently associated with decreases in C (adjusted r(2) = 0.14) and non-HDL-C (adjusted r(2) = 0.20) levels and with a less-pronounced increase in CIMT (adjusted r(2) = 0.14). High FGF23 appears to be an independent biomarker of a decrease in C and non-HDL-C that is negatively associated with atherosclerosis in patients on MHD.
机译：正在进行维持性血液透析（MHD）的终末期肾脏疾病（ESRD）患者经常会升高成纤维细胞生长因子（FGF）23（一种磷酸钙）的水平。然而，由于肾FGF受体功能可能受损，FGF23的作用尚不清楚。本项横断面研究检查了一组未接受过包括司维拉莫在内的降脂药物治疗的MHD患者（n = 196）。在前一次高清透析后的第三天，在血液透析（HD）之前抽取非空腹静脉血样品，以测量白蛋白，钙（Ca），磷酸盐（P），碱性磷酸酶，完整甲状旁腺激素（PTH）的血清水平，总胆固醇（C），高密度脂蛋白（HDL）-C，低密度脂蛋白（LDL）-C，氧化性LDL-C，高敏感性C反应蛋白（HsCRP），白介素6（IL-6 ）和FGF23。营养状况使用老年营养风险指数（GNRI）进行评估。使用B型超声扫描仪评估颈动脉内膜中层厚度（CIMT）。 FGF23与P，Ca（alb）xP乘积和完整PTH呈正相关，与C和非HDL-C呈负相关。与较低的FGF23三分位数相比，在较高的FGF23三分位数中，非HDL-C和C的水平均显着降低，而CIMT的升高幅度较小。多变量分析显示，较高的FGF23三元组独立地与C水平降低（校正后的r（2）= 0.14）和非HDL-C水平相关（校正后的r（2）= 0.20）和CIMT的增加不那么明显（调整后的r（2）= 0.14）。高FGF23似乎是C和非HDL-C下降的独立生物标志物，与MHD患者的动脉粥样硬化负相关。

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