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首页> 外文期刊>Tissue antigens. >HLA polymorphism in a Majorcan population of Jewish descent: Comparison with Majorca, Minorca, Ibiza (Balearic Islands) and other Jewish communities.
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HLA polymorphism in a Majorcan population of Jewish descent: Comparison with Majorca, Minorca, Ibiza (Balearic Islands) and other Jewish communities.

机译：马略卡族犹太血统中的HLA多态性：与马略卡岛，梅诺卡岛，伊维萨岛（巴利阿里群岛）和其他犹太人社区的比较。

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'Chueta' was the name given to the Catholic descendants of Jewish victims of the last Spanish Inquisition process in Majorca Island in the western Mediterranean. We have studied the allele distribution of HLA-A, -B, -Cw, -DRB1 and -DQB1 loci of 103 random, healthy, unrelated individuals belonging to the ancient Majorcan Jewish community, known locally as Chuetas, and 589 individuals from the Balearic population selected because of their typical Balearic - Majorca, Minorca or Ibiza - lineages and according to their ancestor's place of birth. Our aim was to establish the genetic relationship between Majorcan Chuetas, and Balearic and other Jewish and Mediterranean populations. Our results have shown that, to a remarkable extent, they have retained their biological identity, with a unique pattern, in terms of gene and haplotype frequencies, separate from the other populations of Majorca. The Chuetas were found to be more related to Moroccan and Libyan Jews than other Majorcans. Characteristic Jewish haplotypes, A26-B38-DRB1*13, A24-B38-DRB1*11, A1-B52-DRB1*15/16, were found in our study. Some peculiarities were observed in the distribution of common haplotypes among the three main Balearic Islands. The Ibizan population was genetically different from the other Balearic populations, with a high frequency of some haplotypes, for example, A29-Cw*16-B44-DRB1*07-DQB1*03; A1-Cw*07-B8-DRB1*03-DQB1*02. We also found a new haplotype, A25-Cw*12-B39-DRB1*11-DQB1*03(3.5%), in Ibizans and a more limited variability in the HLA alleles that were expressed, perhaps because of genetic isolation. The genetic diversity of the populations from Majorca and Minorca were similar and more related to the mainland Spanish population.
机译：“ Chueta”是地中海西部马略卡岛上一次西班牙宗教裁判所中犹太受害者的天主教后裔的名字。我们研究了属于古代马略卡犹太人社区的103个随机，健康，无亲属关系的人的HLA-A，-B，-Cw，-DRB1和-DQB1基因座的等位基因分布，这些人在当地被称为Chuetas，还有来自巴利阿里的589个人根据典型的巴利阿里人（马略卡岛，米诺卡岛或伊维萨岛）血统选择的人口，并根据其祖先的出生地进行选择。我们的目的是建立马略卡·丘埃塔斯与巴利阿里人以及其他犹太人和地中海人之间的遗传关系。我们的研究结果表明，在基因和单倍型频率方面，它们与马略卡岛的其他种群分开，在很大程度上保留了其生物学特性，并具有独特的模式。人们发现Chuetas与摩洛哥和利比亚犹太人的关系要比其他Majorcan人的更为密切。在我们的研究中发现了特征性的犹太单倍型，即A26-B38-DRB1 * 13，A24-B38-DRB1 * 11，A1-B52-DRB1 * 15/16。在三个主要的巴利阿里群岛之间观察到一些常见的单体型分布情况。伊比桑种群与其他巴利阿里种群在遗传上有所不同，某些单倍型的频率很高，例如A29-Cw * 16-B44-DRB1 * 07-DQB1 * 03; A1-Cw * 07-B8-DRB1 * 03-DQB1 * 02。我们还发现了一个新的单倍型，A25-Cw * 12-B39-DRB1 * 11-DQB1 * 03（3.5％），并且可能是由于遗传分离而在所表达的HLA等位基因中具有更有限的变异性。马略卡岛和梅诺卡岛人口的遗传多样性相似，并且与西班牙大陆人口更相关。

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