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首页> 外文期刊>Tissue antigens. >Association between hepatitis B virus infection and HLA-DRB1 genotyping in Shaanxi Han patients in northwestern China.
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Association between hepatitis B virus infection and HLA-DRB1 genotyping in Shaanxi Han patients in northwestern China.

机译：中国西北地区陕西汉族人群乙肝病毒感染与HLA-DRB1基因分型的关系。

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Hepatitis B virus (HBV) infection is a major public health problem worldwide. The mechanism of susceptibility to chronic persistent HBV infection is not well clarified, while the outcome of HBV infection mainly depends on the host immune response. Human leukocyte antigen (HLA) class II molecule is an integral component of the immune response on which majority of host genetic studies have concentrated. Many different HLA class II alleles have been demonstrated to play roles in HBV infection. In this study, the association between HBV infection and HLA-DRB1 alleles in Han individuals in northwestern China was studied for the first time. Two hundred and fifty Shaanxi Han individuals were categorized into three different groups: the HBV-infected patient group (n = 108), the spontaneously cleared control group (n = 108) and the unexposed group (n = 34). DRB1*04, DRB1*09, DRB1*12 and DRB1*15 were the most common genotypes in all the groups. The allele frequencies of HLA-DRB1*03 [10.6% of HBV-infected patients vs 3.7% of spontaneously cleared controls, odds ratios (OR) = 3.10, Pc = 0.008, P < 0.05] and HLA-DRB1*07 (17.6% of HBV-infected patients vs 9.3% of spontaneously cleared controls, Pc = 0.016, OR = 2.09, P < 0.05) were markedly higher in the HBV-infected group. But the allele frequencies of HLA-DRB1*15 (6.9% of HBV-infected patients vs 13.4% of spontaneously cleared controls Pc = 0.039, OR = 0.48, P < 0.05) were obviously lower than that of the spontaneously cleared controls. The above data indicate that HLA-DRB1*03 and HLA-DRB1*07 are related to susceptibility to chronic HBV infection, and DRB1*15 is negatively related to persistence to chronic HBV infection among people in northwestern China. Similar results were got for DRB1*03 and 15 alleles between the HBV-infected patients (n = 108) and 46 HBV seronegative spouses of the HBV patients, who were high-risk group for HBV infection. The above results suggest that host HLA class II gene is an important factor in determination of the outcome of HBV infection.
机译：乙型肝炎病毒（HBV）感染是全球主要的公共卫生问题。慢性持续性HBV感染的易感性机制尚不清楚，而HBV感染的结果主要取决于宿主的免疫反应。人类白细胞抗原（HLA）II类分子是大多数宿主基因研究都集中在其免疫应答中的组成部分。已证明许多不同的HLA II类等位基因在HBV感染中起作用。在本研究中，首次研究了中国西北汉族人群的HBV感染与HLA-DRB1等位基因之间的关系。将250名陕西汉族人分为三组：HBV感染患者组（n = 108），自发清除对照组（n = 108）和未暴露组（n = 34）。在所有组中，DRB1 * 04，DRB1 * 09，DRB1 * 12和DRB1 * 15是最常见的基因型。 HLA-DRB1 * 03的等位基因频率[10.6％的HBV感染患者与3.7％的自发清除对照者的比较，优势比（OR）= 3.10，Pc = 0.008，P <0.05]和HLA-DRB1 * 07（17.6％感染HBV的患者中，自发清除对照组的9.3％，Pc = 0.016，OR = 2.09，P <0.05）在HBV感染组中明显更高。但是HLA-DRB1 * 15的等位基因频率（感染HBV的患者为6.9％，自发清除的对照组为13.4％，Pc = 0.039，OR = 0.48，P <0.05）明显低于自发清除的对照组。上述数据表明，HLA-DRB1 * 03和HLA-DRB1 * 07与慢性HBV感染的易感性有关，而DRB1 * 15与西北地区人群对慢性HBV感染的持久性负相关。在HBV感染的高危人群中，被HBV感染的患者（n = 108）与46名HBV血清阴性配偶之间的DRB1 * 03和15个等位基因获得了相似的结果。上述结果表明，宿主HLA II类基因是决定HBV感染结局的重要因素。

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