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首页> 外文期刊>Tissue antigens. >Molecular analysis of HLA class I alleles in the Mexican Seri Indians: implications for their origin.
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Molecular analysis of HLA class I alleles in the Mexican Seri Indians: implications for their origin.

机译：墨西哥斯里印第安人中HLA I类等位基因的分子分析：对它们起源的影响。

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The molecular analysis of HLA class I loci has demonstrated that, although, the genetic profile is restricted in Amerindians, several micropolymorphisms may be important in conferring a biological advantage. We analyzed the HLA-A and B genetic profile of Seris, a Mexican Indian tribe living in northwestern Mexico in the state of Sonora. There are presently only 619 individuals. Our study included 100 Seris belonging to nine families. HLA-A and -B loci typing was performed by polymerase chain reaction using an amplification refractory mutation system (PCR-ARMS) on a select group of samples; all of them were typed by polymerase chain reaction using sequence-specific oliogonuoleotide probes (PCR-SSOP) at a low-intermediate resolution level. The correlation between the techniques was 100%. Only five HLA-A alleles and seven HLA-B alleles were found. A*0201, A*68, A*31, A*24, B*3501, B*40, B*51, B*3512 and B*15 were present in over 5% of the individuals. B*27052 was detected in 2%. B27 is absent in any other Mexican Indian groups previously studied. The presence of B27 may be the result of a founder effect due to different waves of southward migrations. The B-locus is more diverse and the prevalent haplotypes were: A*0201-B*3501, A*0201-B*40, A*0201-B*3512, A*31-B*51, A*68-B*3501 and A*68-B*40. This genetic profile is different from the pattern of other Mexicans. The phylogenetic tree suggests that Seris are more closely related to the Warao Indians from Venezuela, who live in a similar ecosystem, and to some groups of Argentina, than they are to the Mexican Lacandones who live in the jungle. These data emphasize the relevance of the interaction between genes and environment.
机译：HLA I类位点的分子分析表明，尽管遗传特征在美洲印第安人中受到限制，但在赋予生物学优势方面，若干微多态性可能很重要。我们分析了居住在索诺拉州墨西哥西北部的墨西哥印第安部落塞里斯的HLA-A和B遗传特征。目前只有619个人。我们的研究包括属于9个家庭的100个Seris。 HLA-A和-B基因座分型是通过聚合酶链反应，使用扩增难治性突变系统（PCR-ARMS）对一组选定的样品进行的;所有这些均通过使用低中间分辨率的序列特异性寡核苷酸探针（PCR-SSOP）通过聚合酶链式反应进行分型。这些技术之间的相关性是100％。仅发现五个HLA-A等位基因和七个HLA-B等位基因。超过5％的个体中存在A * 0201，A * 68，A * 31，A * 24，B * 3501，B * 40，B * 51，B * 3512和B * 15。 B * 27052的检出率为2％。在先前研究的任何其他墨西哥印第安人团体中都没有B27。 B27的存在可能是由于向南迁移的浪潮不同而造成的建立者效应的结果。 B基因座更加多样化，普遍的单体型为：A * 0201-B * 3501，A * 0201-B * 40，A * 0201-B * 3512，A * 31-B * 51，A * 68-B * 3501和A * 68-B * 40。这种遗传特征不同于其他墨西哥人的模式。系统进化树表明，与生活在类似生态系统中的委内瑞拉的瓦拉印第安人以及阿根廷的某些群体相比，塞里斯族与居住在丛林中的墨西哥拉康多人的亲缘关系更为密切。这些数据强调了基因与环境之间相互作用的相关性。

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