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首页> 外文期刊>Tissue antigens. >Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs.
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Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs.

机译：分析德国牧羊犬肛门糠fur病中的NOD1，NOD2，TLR1，TLR2，TLR4，TLR5，TLR6和TLR9基因。

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摘要

Anal furunculosis (AF) primarily affects German shepherd dogs (GSD) and is characterised by inflammation and ulceration of the perianal tissues with development of cutaneous sinuses or rectocutaneous fistulae. Investigation of pattern recognition receptor (PRR) function has suggested that defective responses might occur in AF-affected GSD. The aim of the current study was to investigate whether canine PRR genes are involved in determining susceptibility to AF in this breed. Chromosomal location and coding sequences for NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 were determined and microsatellite markers identified for each gene. Microsatellite genotyping of 100 control GSD and 47 AF-affected GSD showed restricted allelic variation for AHT H91 (associated with TLR5) and REN216 NO5 (associated with both TLR1 and TLR6) compared with non-GSD dogs. Genotyping of single nucleotide polymorphisms identified in canine TLR1, TLR5, TLR6 and NOD2 genes failed to show any significant associations between PRRpolymorphisms and AF. The highly restricted PRR genotypes seen in GSD are likely to have resulted from selective breeding and might influence innate immune responses in this breed.
机译：肛门真菌病（AF）主要影响德国牧羊犬（GSD），其特征是肛周组织发炎和溃疡，并伴有皮肤窦或直肠瘘。对模式识别受体（PRR）功能的研究表明，在受AF影响的GSD中可能出现不良反应。本研究的目的是调查犬的PRR基因是否参与确定该品种对AF的敏感性。确定了NOD1，NOD2，TLR1，TLR2，TLR4，TLR5，TLR6和TLR9的染色体位置和编码序列，并为每个基因鉴定了微卫星标记。与非GSD犬相比，100个对照GSD和47个受AF影响的GSD的微卫星基因分型显示AHT H91（与TLR5相关）和REN216 NO5（与TLR1和TLR6相关）的等位基因变异受到限制。在犬TLR1，TLR5，TLR6和NOD2基因中鉴定出的单核苷酸多态性的基因分型未能显示出PRR多态性与AF之间的任何重要关联。在GSD中观察到的高度限制性PRR基因型可能是选择性育种产生的，并且可能影响该品种的先天免疫应答。

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