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首页> 外文期刊>Thyroid: official journal of the American Thyroid Association >Familial aggregation of autoimmune thyroiditis in first-degree relatives of patients with juvenile autoimmune thyroid disease.
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Familial aggregation of autoimmune thyroiditis in first-degree relatives of patients with juvenile autoimmune thyroid disease.

机译：少年自身免疫性甲状腺疾病患者一级亲属的自身免疫性甲状腺炎家族聚集。

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Several studies have shown aggregation of autoimmune thyroiditis in families by estimation of thyroid antibodies. However, the prevalence by concurrent estimation with fine-needle aspiration cytology (FNAC) and thyroid antibodies has not been previously reported. We therefore studied 222 first-degree relatives (group 1) of 71 index cases diagnosed as lymphocytic thyroiditis on FNAC and 81 family members (group 2) of 23 goitrous children diagnosed as colloid goiter on FNAC for comparison. Successful FNAC conducted in 122 group 1 subjects revealed lymphocytic thyroiditis in 51 (42%), whereas lymphocytic thyroiditis was diagnosed in only 5 goitrous subjects (13%) in group 2. Among group 1 subjects with FNAC-proven lymphocytic thyroiditis, antithyroid peroxidase (TPO) antibodies were found in 35 (67%), while in anti-TPO antibody positive goitrous relatives of group 1, lymphocytic thyroiditis was found in 36 (78%). Eight new cases of overt hypothyroidism and 45 new cases of subclinical hypothyroidism were diagnosed among group 1 subjects. Our study suggests: (1) familial clustering of autoimmune thyroiditis; (2) if only FNAC or thyroid antibodies is used for diagnosis of autoimmune thyroiditis in children, 22%-33% of cases are likely to be missed; and (3) serum thyrotropin (TSH) should be offered to all first-degree relatives of patients with juvenile autoimmune thyroiditis.
机译：多项研究表明，通过评估甲状腺抗体可发现自身免疫性甲状腺炎在家庭中的聚集。然而，先前尚未报道通过同时进行细针穿刺细胞学检查（FNAC）和甲状腺抗体评估的患病率。因此，我们比较了71例在FNAC上被诊断为淋巴细胞性甲状腺炎的索引病例的222个一级亲属（第1组）和23例在FNAC上被诊断为胶体甲状腺肿的儿童的81个家庭成员（第2组）。在第1组122例受试者中成功进行了FNAC，其中51例（42％）淋巴结性甲状腺炎，而在第2组中只有5例甲状腺肿受试者（13％）被诊断出淋巴性甲状腺炎。第35组（67％）发现了TPO）抗体，而在第1组的抗TPO阳性亲戚中发现了36​​例（78％）甲状腺甲状腺炎。在第1组受试者中，诊断出8例新的明显的甲状腺功能减退和45例新的亚临床甲状腺功能减退。我们的研究提示：（1）家族性自身免疫性甲状腺炎的聚集; （2）如果仅将FNAC或甲状腺抗体用于儿童自身免疫性甲状腺炎的诊断，则有22％-33％的病例很可能会漏诊; （3）应向所有青少年自身免疫性甲状腺炎患者的所有一级亲属提供血清促甲状腺激素（TSH）。

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