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首页> 外文期刊>Thyroid: official journal of the American Thyroid Association >Immunostaining for ret oncogene proteins in papillary thyroid carcinoma: a correlation of ret immunoreactivity and potential of lymph node metastasis.
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Immunostaining for ret oncogene proteins in papillary thyroid carcinoma: a correlation of ret immunoreactivity and potential of lymph node metastasis.

机译：甲状腺乳头状癌中视网膜癌基因蛋白的免疫染色：视网膜免疫反应性与淋巴结转移潜能的相关性。

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Ret oncogenes, particularly Ret/PTC, have been associated with the potential of local invasion of papillary thyroid carcinoma (PTC). The purpose of this study was to investigate the correlation between the Ret oncogene expression and the potential of lymph node metastasis of PTC. A total of 107 PTC were microscopically reviewed to identify areas of infiltrating carcinoma (IC). IC was defined as tumor cells disposed in a haphazard pattern and in lobules, nests, follicles, or single cells within a desmoplastic or sclerotic stroma. All cases were submitted to immunostaining for Ret oncogene. There were 36 noninfiltrating PTC with lymph node metastasis in 1 case and 71 infiltrating PTC with lymph node metastasis in 40 cases. For non-PTC, the positive immunoreactivity was often weak to moderate and focal. For infiltrating PTC with IC, the IC displayed strong immunoreactivity. The noninfiltrating component of PTC with IC usually showed stronger reactivity than PTC without an infiltrating component. Furthermore, 36 of 40 metastatic PTC in lymph node were immunoreactive. Three follicular adenomas with areas of scar caused by fine-needle aspiration biopsy were not immunoreactive for Ret. In view of the high potential of infiltrating PTC for lymph node metastasis, distinction of this type of carcinoma from its noninfiltrating form is clinically important. Because immunoreactivity for Ret is usually positive in areas of infiltrating PTC and is often negative or focally positive in noninfiltrating PTC, immunostaining for Ret is helpful to identify infiltrating PTC and distinguish it from changes caused by fine-needle aspiration biopsy in benign thyroid lesions.
机译：致癌基因，特别是Ret / PTC，与乳头状甲状腺癌（PTC）的局部侵袭潜力有关。本研究的目的是研究Ret癌基因表达与PTC淋巴结转移潜能之间的相关性。总共对107个PTC进行了显微镜检查，以鉴定浸润癌（IC）的区域。 IC被定义为以散乱的方式分布在增生或硬化性基质中的小叶，巢，卵泡或单个细胞中的肿瘤细胞。所有病例均接受了Ret癌基因的免疫染色。淋巴结转移的非浸润性PTC 36例1例，淋巴结转移的浸润性PTC 71例40例。对于非PTC，阳性免疫反应性通常弱至中度和局灶性。对于用IC渗透PTC，IC表现出很强的免疫反应性。具有IC的PTC的非渗透成分通常比没有渗透成分的PTC具有更强的反应性。此外，在淋巴结转移的40个PTC中，有36个具有免疫反应性。 3例细针穿刺活检引起的瘢痕性滤泡性腺瘤对Ret无免疫反应性。鉴于浸润性PTC在淋巴结转移中的潜力很大，因此将这种类型的癌与其非浸润型区别开来在临床上很重要。由于Ret的免疫反应性通常在浸润性PTC区域中呈阳性，而在非浸润性PTC中通常呈阴性或局灶性阳性，因此Ret的免疫染色有助于识别浸润性PTC，并将其与甲状腺良性病变的细针穿刺活检引起的变化区分开来。

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