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首页> 外文期刊>Tissue engineering, Part B. Reviews >The application of induced pluripotent stem cells for bone regeneration: Current progress and prospects
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The application of induced pluripotent stem cells for bone regeneration: Current progress and prospects

机译：诱导多能干细胞在骨再生中的应用：当前进展与展望

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Loss of healthy bone tissue and dysosteogenesis are still common and significant problems in clinics. Cell-based therapy using mesenchymal stem cells (MSCs) has been performed in patients for quite some time, but the inherent drawbacks of these cells, such as the reductions in proliferation rate and osteogenic differentiation potential that occur with aging, greatly limit their further application. Moreover, embryonic stem cells (ESCs) have brought new hope to osteoregenerative medicine because of their full pluripotent differentiation potential and excellent performance in bone regeneration. However, the ethical issues involved in destroying human embryos and the immune reactions that occur after transplantation are two major stumbling blocks impeding the clinical application of ESCs. Instead, induced pluripotent stem cells (iPSCs), which are ESC-like pluripotent cells that are reprogrammed from adult somatic cells using defined transcription factors, are considered a more promising source of cells for regenerative medicine because they present no ethical or immunological issues. Here, we summarize the primary technologies for generating iPSCs and the biological properties of these cells, review the current advances in iPSC-based bone regeneration and, finally, discuss the remaining challenges associated with these cells, particularly safety issues and their potential application for osteoregenerative medicine.
机译：健康的骨组织损失和骨发育不良仍是临床中常见的重大问题。已经在患者中进行了使用间充质干细胞（MSC）的基于细胞的治疗已有相当长的时间，但是这些细胞的固有缺点，例如随着年龄的增长而导致的增殖率降低和成骨分化潜能的降低，极大地限制了它们的进一步应用。 。此外，胚胎干细胞（ESC）由于具有充分的多能分化潜能和出色的骨再生性能，因此为骨再生医学带来了新的希望。然而，破坏人类胚胎和移植后发生的免疫反应所涉及的伦理问题是阻碍ESCs临床应用的两个主要障碍。取而代之的是诱导多能干细胞（iPSC），它们是ESC样的多能细胞，可以使用定义的转录因子从成年体细胞中重新编程，因为它们不存在伦理或免疫学问题，因此被认为是用于再生医学的更有希望的细胞来源。在这里，我们总结了产生iPSC的主要技术和这些细胞的生物学特性，回顾了基于iPSC的骨再生的最新进展，最后讨论了与这些细胞相关的剩余挑战，特别是安全性问题及其在骨再生中的潜在应用药物。

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