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首页> 外文期刊>Toxicological reviews >Does urine alkalinization increase salicylate elimination? If so, why?
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Does urine alkalinization increase salicylate elimination? If so, why?

机译：尿碱化会增加水杨酸盐的消除吗？如果是这样，为什么？

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Urine alkalinization is a treatment regimen that increases poison elimination by the administration of intravenous sodium bicarbonate to produce urine with a pH > or = 7.5. Experimental and clinical studies confirm that urinary alkalinization increases salicylate elimination, although the mechanisms by which this occurs have not been elucidated. The conventional view is that ionisation of a weak acid, such as salicylic acid, is increased in an alkaline environment. Since the ionisation constant (pKa) is a logarithmic function then, theoretically, a small change in urine pH will have a disproportionately larger effect on salicylate clearance. Hence, elimination of salicylic acid by the kidneys is increased substantially in alkaline urine. However, as salicylic acid is almost completely ionised within physiological pH limits, alkalinization of the urine could not, therefore, significantly increase the extent of ionisation further and the conventional view of the mechanism by which alkalinization is effective is patently impossible. Further experimental studies are required to clarify the mechanisms by which urine alkalinization enhances salicylate elimination.
机译：尿碱化是一种治疗方案，可通过静脉注射碳酸氢钠来产生pH>或= 7.5的尿液，从而增加除毒效果。实验和临床研究证实，尿碱化增加了水杨酸盐的消除，尽管尚未阐明其发生的机理。传统观点认为，在碱性环境中，弱酸（例如水杨酸）的电离会增加。由于电离常数（pKa）是对数函数，因此从理论上讲，尿液pH值的微小变化会对水杨酸盐的清除产生不成比例的较大影响。因此，在碱性尿液中，肾脏对水杨酸的消除显着增加。然而，由于水杨酸在生理学pH极限内几乎完全被电离，因此尿液的碱化不能进一步显着增加电离程度，并且传统上对碱化有效机理的看法显然是不可能的。需要进一步的实验研究来阐明尿碱化增强水杨酸盐消除的机理。

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