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首页> 外文期刊>Toxicological reviews >The potential adverse health effects of dental amalgam.
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The potential adverse health effects of dental amalgam.

机译：牙科汞合金对健康的潜在不利影响。

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There is significant public concern about the potential health effects of exposure to mercury vapour (Hg(0)) released from dental amalgam restorations. The purpose of this article is to provide information about the toxicokinetics of Hg(0), evaluate the findings from the recent scientific and medical literature, and identify research gaps that when filled may definitively support or refute the hypothesis that dental amalgam causes adverse health effects.Dental amalgam is a widely used restorative dental material that was introduced over 150 years ago. Most standard dental amalgam formulations contain approximately 50% elemental mercury. Experimental evidence consistently demonstrates that Hg(0) is released from dental amalgam restorations and is absorbed by the human body. Numerous studies report positive correlations between the number of dental amalgam restorations or surfaces and urine mercury concentrations in non-occupationally exposed individuals. Although of public concern, it is currently unclear what adverse health effects are caused by the levels of Hg(0) released from this restoration material. Historically, studies of occupationally exposed individuals have provided consistent information about the relationship between exposure to Hg(0) and adverse effects reflecting both nervous system and renal dysfunction. Workers are usually exposed to substantially higher Hg(0) levels than individuals with dental amalgam restorations and are typically exposed 8 hours per day for 20-30 years, whereas persons with dental amalgam restorations are exposed 24 hours per day over some portion of a lifetime. This review has uncovered no convincing evidence pointing to any adverse health effects that are attributable to dental amalgam restorations besides hypersensitivity in some individuals.
机译：公众对从牙科用汞合金修复物中释放的汞蒸气（Hg（0））的潜在健康影响极为关注。本文的目的是提供有关Hg（0）的毒物动力学的信息，评估最近科学和医学文献中的发现，并确定研究空白，以填补这些空白可能会最终支持或反驳牙科用汞合金会导致不良健康影响的假设。牙科汞合金是一种广泛使用的修复性牙科材料，于150年前被引入。大多数标准牙科用汞合金配方均含有约50％的元素汞。实验证据一致地证明，Hg（0）从牙科用汞合金修复物中释放出来并被人体吸收。大量研究报告了在非职业暴露人群中，牙齿汞齐修复物或表面的数量与尿中汞的浓度之间呈正相关。尽管引起了公众的关注，但目前尚不清楚此修复材料释放出的Hg（0）的水平会对健康产生什么不利影响。从历史上看，对职业接触者的研究提供了有关暴露于Hg（0）与反映神经系统和肾功能障碍的不良反应之间关系的一致信息。与具有牙科用汞合金修复的个体相比，工人通常暴露于显着更高的Hg（0）水平，并且通常每天暴露8小时，持续20-30年，而具有牙科用汞合金修复的个体在一天的一生中每天暴露24小时。 。这篇评论没有发现有说服力的证据表明除了某些人的超敏反应之外，由于牙科用汞齐修复所引起的任何不良健康影响。

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