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首页> 外文期刊>Toxicological sciences: An official journal of the Society of Toxicology >Acute and subchronic mammalian toxicity of naphthenic acids from oil sands tailings.
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Acute and subchronic mammalian toxicity of naphthenic acids from oil sands tailings.

机译：油砂尾矿中环烷酸的急性和亚慢性哺乳动物毒性。

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Naphthenic acids are the most significant environmental contaminants resulting from petroleum extraction from oil sands deposits. In this study, a mixture of naphthenic acids isolated from Athabasca oil sands (AOS) tailings pond water was used in acute and subchronic toxicity tests with rodents, in order to assess potential risks posed to terrestrial wildlife. Dosages were chosen to bracket worst-case environmental exposure scenarios. In acute tests, adult female Wistar rats were given single po dosages of naphthenic acids at either 3, 30, or 300 mg per kg body weight (mg/kg), while adult male rats received 300 mg/kg. Food consumption was temporarily suppressed in the high-dose groups of both sexes. Following euthanasia 14 days later, histopathology revealed a significant incidence of pericholangitis in the high-dose group of both sexes, suggesting hepatotoxicity as an acute effect. Other histological lesions included brain hemorrhage in high-dose males, and cardiac periarteriolar necrosis and fibrosis in female rats. In subchronic tests, naphthenic acids were po administered to female Wistar rats at 0.6, 6, or 60 mg/kg, 5 days per week for 90 days. Results again suggested the liver as a potential target organ. The relative liver weight in the high-dose group was 35% higher than in controls. Biochemical analysis revealed elevated blood amylase (30% above controls) and hypocholesterolemia (43% below controls) in high-dose rats. Excessive hepatic glycogen accumulation was observed in 42% of animals in this group. These results indicate that, under worst-case exposure conditions, acute toxicity is unlikely in wild mammals exposed to naphthenic acids in AOS tailings pond water, but repeated exposure may have adverse health effects.
机译：环烷酸是从油砂沉积物中提取石油所产生的最重要的环境污染物。在这项研究中，从阿萨巴斯卡油砂（AOS）尾矿池水中分离出的环烷酸混合物用于啮齿类动物的急性和亚慢性毒性试验中，以评估其对陆生野生生物的潜在风险。选择剂量以应对最坏的环境暴露情况。在急性试验中，成年雌性Wistar大鼠单剂量口服环烷酸，剂量为3、30或300 mg / kg体重（mg / kg），成年雄性大鼠接受300 mg / kg。男女高剂量组的食物消耗暂时受到抑制。安乐死14天后，组织病理学检查发现高剂量的男女均患有胆管周围炎，这是急性毒性。其他组织学损伤包括大剂量雄性大鼠脑出血，雌性大鼠心脏小动脉周围坏死和纤维化。在亚慢性测试中，以0.6、6或60 mg / kg的剂量每周5天向雌性Wistar大鼠口服环烷酸90天。结果再次表明肝脏是潜在的靶器官。高剂量组的相对肝脏重量比对照组高35％。生化分析显示，大剂量大鼠血液淀粉酶升高（比对照组高30％）和低胆固醇血症（比对照组低43％）。在该组中42％的动物中观察到肝糖原过多积累。这些结果表明，在最坏的情况下，暴露于AOS尾矿池水中环烷酸的野生哺乳动物不太可能出现急性毒性，但反复接触可能对健康造成不利影响。

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