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首页> 外文期刊>Thermochimica Acta: An International Journal Concerned with the Broader Aspects of Thermochemistry and Its Applications to Chemical Problems >STUDY ON THE THERMOSENSITIVITY OF A TUMOR CELL BY MICROCALORIMETRY
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STUDY ON THE THERMOSENSITIVITY OF A TUMOR CELL BY MICROCALORIMETRY

机译：微量热法研究肿瘤细胞的热敏性

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Power-time curves of the growth of a tongue cancer cell line (CP2) and a normal human embryonic lung cell line (Fu(2)P(1)) have been determined by a microcalorimeter at 37 degrees C and 45 degrees C, respectively. The experiments showed that the ratio of the maximal thermal power of both kings of cell growth, P-max (CP2, 37 degrees C/P-max (Fu(2)P(1), 37 degrees C), equalled 1.74 at 37 degrees C, while at 45 degrees C, P-max (CP2, 45 degrees C)/P-max (Fu(2)P(1)), 45 degrees C) = 0.464. The ratio of the metabolic heat for both kinds of cell growing for 63 h at 37 degrees C is, Q (CP2, 37 degrees C)/Q(Fu(2)P(1), 37 degrees C) = 2.295, while at 45 degrees C after both kinds of cells grow for 15 h, Q(CP2, 45 degrees C)/Q(Fu(2)P(1), 45 degrees C) = 0.686. As a comparison, Q(CP2, 37 degrees C)/Q(CP2, 45 degrees C) = 1.734, Q(Fu(2)P(1), 37 degrees C)/Q(Fu(2)P(1), 45 degrees C) = 0.502. The results indicate that the metabolic activity value of the tumor cell is distinctly higher than that of nontumor cell at 37 degrees C, but lower at 45 degrees C. By means of microcalorimetry, it is demonstrated that temperature has a remarkably selective destructuring effect of heat against tumor cell. The results of 6 other kinds of cancer cells and normal cells at different temperatures are also in agreement with the results obtained. Also, the power-time curves of the two passages of the tongue cancer cell (P-6 and P-7) are determined. The difference between the two passages is shown clearly on the power-time curves. It is concluded that microcalorimetry could be used as a powerful tool to characterize the passages of the cell. (C) 1997 Elsevier Science B.V. [References: 21]
机译：分别通过微热量计在37摄氏度和45摄氏度下确定了舌癌细胞系（CP2）和正常人胚胎肺细胞系（Fu（2）P（1））生长的功率-时间曲线。 。实验表明，两个细胞生长之王的最大热功率之比P-max（CP2，37摄氏度/ P-max（Fu（2）P（1），37摄氏度），在37时等于1.74摄氏度，而在45摄氏度时，P-max（CP2，45摄氏度）/ P-max（Fu（2）P（1）），45摄氏度）= 0.464。两种细胞在37摄氏度下生长63小时的代谢热之比为Q（CP2，37摄氏度）/ Q（Fu（2）P（1），37摄氏度）= 2.295两种细胞生长15小时后的45摄氏度，Q（CP2，45摄氏度）/ Q（Fu（2）P（1），45摄氏度）= 0.686。作为比较，Q（CP2，37摄氏度）/ Q（CP2，45摄氏度）= 1.734，Q（Fu（2）P（1），37摄氏度）/ Q（Fu（2）P（1） 45度）= 0.502。结果表明，在37℃时，肿瘤细胞的代谢活性值明显高于非肿瘤细胞，而在45℃时则较低。通过微量量热法，表明温度具有明显的热选择性破坏作用。针对肿瘤细胞。其他6种癌细胞和正常细胞在不同温度下的结果也与所得结果一致。而且，确定了舌癌细胞的两个通道（P-6和P-7）的功率-时间曲线。功率时间曲线上清楚显示了两个通道之间的差异。结论是微量量热法可用作表征细胞传代的有力工具。 （C）1997 Elsevier Science B.V. [参考：21]

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