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首页> 外文期刊>Toxicology and Industrial Health >Reducing the inhibitory effect of cigarette smoke on the activity of oral peroxidase by the addition of berberine in cigarette filter
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Reducing the inhibitory effect of cigarette smoke on the activity of oral peroxidase by the addition of berberine in cigarette filter

机译：通过在卷烟滤嘴中添加小ber碱减少卷烟烟气对口服过氧化物酶活性的抑制作用

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This study was carried out to evaluate the effect of cigarette smoke (CS) on the activity of oral peroxidase (OPO) after berberine was added to the cigarette filter. Activated carbon fiber (ACF) was chosen to load berberine as a part of the cellulose acetate (CA) filter to obtain the modified B-ACF cigarette filter. Then the effects of CS from the testing cigarettes on the activity of OPO were investigated in vitro by the 2-nitrobenzoic acid assay, and the smoke chemistry was also analyzed, especially the content of hydrogen cyanide (HCN) in the CS. The results indicated that the loss of activity of OPO in B-ACF filter cigarette group decreased by 20% and 25%, compared with those of ACF and CA filter cigarette groups, respectively. The relative residual activity of OPO in B-ACF filter group was increased with the increase of berberine in the filter compared with the CA filter group. It could be observed that the reduction in HCN might be related to the berberine in the cigarette filter, reducing the inhibition of CS on the activity of OPO.
机译：进行了这项研究，以评估将黄连素添加到香烟过滤嘴中后，香烟烟雾（CS）对口服过氧化物酶（OPO）活性的影响。选择活性炭纤维（ACF）装载小碱作为醋酸纤维素（CA）过滤嘴的一部分，以获得改性的B-ACF卷烟过滤嘴。然后，通过2-硝基苯甲酸试验研究了香烟中CS对OPO活性的影响，并分析了烟气的化学成分，尤其是CS中氰化氢的含量。结果表明，与ACF和CA滤嘴香烟组相比，B-ACF滤嘴香烟组的OPO活性损失分别降低了20％和25％。与CA过滤组相比，B-ACF过滤组中OPO的相对残余活性随黄连素的增加而增加。可以观察到，HCN的减少可能与香烟过滤嘴中的小ber碱有关，从而减少了CS对OPO活性的抑制作用。

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